Huang Bin, Wang Yilun, Chen Xuguang, Wu Yue, Xu Kaidi, Xie Simeng, Qin Ziyang, Liu Xiang, Chen Huangqin, Li Yuesheng
Department of Stomatology, School of Stomatology and Ophthalmology, Hubei University of Science and Technology, Xianning 437100, China.
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, Hubei University of Science and Technology, Xianning 437100, China.
Molecules. 2025 Jan 22;30(3):487. doi: 10.3390/molecules30030487.
Photodynamic therapy (PDT) holds considerable promise for advancing anticancer treatment, owing to its precision and minimally invasive nature. In this study, we successfully synthesized a series of titanium carbide (TiC, TC)/graphitic carbon nitride (g-CN, CN) nanocomposite through a synergistic approach combining electron beam irradiation and 2D/2D composite formation. According to the results, 1TC/200-CN (1TC, which TC was 1, referred to the mass ratio; 200-CN, which CN was 200 kGy, referred to the irradiation metering) displayed a 94% degradation rate of methylene blue (10 mg/L) in 100 min. Furthermore, the proliferation rate of CAL-27 cells was suppressed to just 23.3% at a concentration of 320 μg/mL of 1TC/200-CN. Notably, the group treated with this concentration exhibited the largest residual scratch area, accompanied by a notable decrease in mitochondrial membrane potential. These enhanced effects were attributed to the efficient transfer of electron-hole pairs facilitated by the TC/CN composite. Our findings not only contribute to the development of efficient and stable nanocomposites for PDT applications but also provide valuable insights into the utilization of nanomaterials in the biomedical field, thereby paving the way for potential breakthroughs in cancer treatment.
光动力疗法（PDT）因其精确性和微创性，在推进抗癌治疗方面具有巨大潜力。在本研究中，我们通过电子束辐照与二维/二维复合材料形成相结合的协同方法，成功合成了一系列碳化钛（TiC，TC）/石墨相氮化碳（g-CN，CN）纳米复合材料。结果表明，1TC/200-CN（1TC中TC为1，指质量比；200-CN中CN为200 kGy，指辐照剂量）在100分钟内对亚甲基蓝（10 mg/L）的降解率达94%。此外，在1TC/200-CN浓度为320 μg/mL时，CAL-27细胞的增殖率仅被抑制至23.3%。值得注意的是，该浓度处理组的残余划痕面积最大，同时线粒体膜电位显著下降。这些增强效应归因于TC/CN复合材料促进了电子-空穴对的有效转移。我们的研究结果不仅有助于开发用于光动力疗法的高效稳定纳米复合材料，还为纳米材料在生物医学领域的应用提供了有价值的见解，从而为癌症治疗的潜在突破铺平了道路。
