Watanabe K, Makino K
Ann Plast Surg. 1985 Mar;14(3):284-95. doi: 10.1097/00000637-198503000-00014.
Because heat and many poisonous chemicals are generated in a fire, studies of inhalation burns have tended to focus on injury by heat and irritative chemicals. In view of the frequent carbon monoxide (CO) poisoning associated with burn deaths and in patients with inhalation burns, however, nonirritative poisonous gases such as CO cannot be disregarded as possible causative factors involved in the production of inhalation burns. Accordingly, we attempted to clarify in animals the effect of nonlethal CO poisoning on inhalation burns due to heated air. The experimental results indicate that inhaling an amount of moderately heated dry air that alone could not cause pulmonary injury produces severe pulmonary injury in the presence of CO. This seems to occur because CO poisoning causes hyperventilation and thus allows a massive amount of heat to reach the lung.
由于火灾会产生热量和许多有毒化学物质，吸入性烧伤的研究往往集中在热和刺激性化学物质造成的损伤上。然而，鉴于与烧伤死亡相关以及吸入性烧伤患者中经常出现一氧化碳（CO）中毒的情况，像CO这样的无刺激性有毒气体作为吸入性烧伤产生的可能致病因素不能被忽视。因此，我们试图在动物身上阐明非致死性CO中毒对热空气所致吸入性烧伤的影响。实验结果表明，吸入一定量单独不会导致肺损伤的适度加热的干燥空气，在有CO存在的情况下会产生严重的肺损伤。这似乎是因为CO中毒导致过度通气，从而使大量热量到达肺部。
