Strbačko I, Radoš M, Jurjević I, Orešković D, Klarica M
Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
Department of Neurology, University Hospital Centre Zagreb, Zagreb, Croatia.
Front Hum Neurosci. 2025 Jan 29;18:1463740. doi: 10.3389/fnhum.2024.1463740. eCollection 2024.
It is generally accepted that during body position changes from horizontal to vertical there is a short-lasting shift of a certain CSF volume from the cranium into the hydrostatically lower parts of the spinal space, which leads to transitory CSF pressure decrease to negative values.
In order to test this, we performed MRI volumetry of cranial and spinal part of the CSF space in healthy volunteers of both genders ( = 22) in three different body positions [horizontal (H); elevated head and upper body (H-UP) under an angle about 30° from the base; elevated lower body (B-UP) under an angle about 30° from the base].
Volumes of brain and spinal cord tissue did not change during body position changes. Significant CSF volume (ml) changes occur inside the spinal space in the tested body positions, primarily in the lumbosacral segment (H-UP - 38.1 ± 7.0; H - 34.4 ± 6.5; B-UP - 28.7 ± 6.5), while at the same time no significant CSF volume changes have been observed inside the cranium in two tested positions (H and B-UP) in which it was possible to measure intracranial CSF volume changes or if we sum up cervical and cranial CSF volumes in those positions.
Observed results suggest that during the changes of body position CSF volume redistribution occurs, primarily inside the spinal and not the cranial space. This is in accordance with the new hypothesis by which spinal intradural space can significantly change its volume due to its elasticity, thus adjusting to the influence of gravity and pressure changes.
人们普遍认为，在身体姿势从水平变为垂直的过程中，一定量的脑脊液会有短暂的转移，从颅骨进入脊柱空间中静水压较低的部位，这会导致脑脊液压力暂时降至负值。
为了验证这一点，我们对22名健康志愿者（男女均有）在三种不同身体姿势下[水平位（H）；头部和上身抬高（H-UP），与基线成约30°角；下身抬高（B-UP），与基线成约30°角]进行了脑脊液空间颅部和脊柱部分的MRI容积测量。
身体姿势改变期间，脑和脊髓组织的体积没有变化。在测试的身体姿势下，脊柱空间内脑脊液体积发生了显著变化（毫升），主要在腰骶段（H-UP - 38.1±7.0；H - 34.4±6.5；B-UP - 28.7±6.5），而与此同时，在两个可测量颅内脑脊液体积变化的测试姿势（H和B-UP）中，或者在将这些姿势下的颈段和颅段脑脊液体积相加时，未观察到颅骨内脑脊液体积有显著变化。
观察结果表明，在身体姿势改变过程中会发生脑脊液体积重新分布，主要发生在脊柱空间而非颅骨空间内。这与新的假说相符，即脊柱硬膜内空间因其弹性可显著改变其体积，从而适应重力和压力变化的影响。
