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本文引用的文献

1
Does COVID-19 cause or worsen LUT dysfunction, what are the mechanisms and possible treatments? ICI-RS 2023.新冠病毒是否会导致或加重 LUT 功能障碍,其机制和可能的治疗方法是什么?ICI-RS 2023 会议。
Neurourol Urodyn. 2024 Aug;43(6):1458-1463. doi: 10.1002/nau.25441. Epub 2024 Mar 20.
2
Viral lumbosacral radiculitis (Elsberg syndrome) in Denmark.丹麦的病毒性腰骶神经根炎(Elsberg 综合征)。
Infection. 2024 Jun;52(3):839-846. doi: 10.1007/s15010-023-02113-9. Epub 2023 Nov 2.
3
COVID-19-Induced Bladder and Bowel Incontinence: A Hidden Morbidity?新冠病毒感染所致膀胱和肠道失禁:一种隐匿的发病率?
Clin Pediatr (Phila). 2024 Jan;63(1):10-13. doi: 10.1177/00099228231167844. Epub 2023 Apr 17.
4
COVID-19 associated lower urinary tract symptoms in children.儿童 COVID-19 相关下尿路症状。
J Pediatr Urol. 2022 Oct;18(5):680.e1-680.e7. doi: 10.1016/j.jpurol.2022.08.018. Epub 2022 Sep 6.
5
Urodynamically proven lower urinary tract dysfunction in children after COVID-19: A case series.儿童 COVID-19 后尿动力学证实的下尿路功能障碍:病例系列。
Low Urin Tract Symptoms. 2022 Jul;14(4):301-304. doi: 10.1111/luts.12436. Epub 2022 Mar 15.
6
COVID-19 in Children: Where do we Stand?儿童 COVID-19:我们处于什么位置?
Arch Med Res. 2022 Jan;53(1):1-8. doi: 10.1016/j.arcmed.2021.07.002. Epub 2021 Jul 6.
7
Neurological complications in pediatric patients with SARS-CoV-2 infection: a systematic review of the literature.儿童 SARS-CoV-2 感染患者的神经系统并发症:文献系统综述。
Ital J Pediatr. 2021 Jun 2;47(1):123. doi: 10.1186/s13052-021-01066-9.
8
A Case of Elsberg Syndrome in the Setting of Asymptomatic SARS-CoV-2 Infection.无症状 SARS-CoV-2 感染背景下的 Elsberg 综合征一例。
J Clin Neuromuscul Dis. 2021 Jun 1;22(4):228-231. doi: 10.1097/CND.0000000000000369.
9
COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC).COVID-19 炎症导致尿液细胞因子升高,并导致 COVID-19 相关性膀胱炎(CAC)。
Med Hypotheses. 2020 Dec;145:110375. doi: 10.1016/j.mehy.2020.110375. Epub 2020 Nov 5.
10
SARS-CoV-2 infection in pediatric population.儿童人群中的新型冠状病毒2型感染。
Acta Biomed. 2020 Sep 15;91(11-S):e2020003. doi: 10.23750/abm.v91i11-S.10298.

儿童新型冠状病毒肺炎后神经源性下尿路功能障碍:一组临床表现类似埃尔茨伯格综合征的病例系列

Post-COVID-19 neurogenic lower urinary tract dysfunction in pediatrics: A case series of clinical manifestations resembling Elsberg syndrome.

作者信息

Mosiello Giovanni, Barone Giulia, Pellegrino Chiara, Barretta Ida, Sollini Maria Laura, Castelli Enrico, Bella Gessica Della, Deanesi Noemi, Paolella Gaia, Capitanucci Maria Luisa

机构信息

Division of Neuro-Urology, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare IRCCS, Rome, 00165 Italy.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), School of Medicine, University of Genoa, Genoa, 16132 Italy.

出版信息

Bladder (San Franc). 2025 Jan 10;11(4):e21200024. doi: 10.14440/bladder.2024.0043. eCollection 2024.

DOI:10.14440/bladder.2024.0043
PMID:39944516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11810686/
Abstract

BACKGROUND

Among the numerous complications associated with post-coronavirus disease 2019 (COVID-19) syndrome, neurogenic lower urinary tract dysfunction (NLUTD) has been rarely reported, particularly in the pediatric population.

CASE PRESENTATION

This report presented three pediatric cases of NLUTD that developed following severe acute respiratory syndrome coronavirus 2 infection, with clinical features resembling Elsberg syndrome. These cases were notable for the severity of their urinary symptoms, which required specialized and individualized bladder management strategies. This case series aims to raise awareness of this emerging clinical condition, which may be underdiagnosed in children recovering from COVID-19. Pediatricians, general practitioners, and urologists should be vigilant in considering NLUTD as a potential diagnosis in children presenting with new or unexplained urinary symptoms. Early diagnosis and timely management are crucial to address these symptoms effectively and prevent potential complications, such as irreversible upper urinary tract damage or long-term bladder dysfunction.

CONCLUSION

Further investigations are warranted to clarify the pathophysiological mechanisms underlying post-COVID-19 NLUTD. Moreover, long-term follow-up studies are needed to better understand the natural history and implications of this condition in the pediatric population, as well as to develop effective strategies for prevention and treatment.

摘要

背景

在与2019冠状病毒病(COVID-19)综合征相关的众多并发症中,神经源性下尿路功能障碍(NLUTD)鲜有报道,尤其是在儿科人群中。

病例报告

本报告介绍了3例严重急性呼吸综合征冠状病毒2感染后发生的儿科NLUTD病例,其临床特征类似于埃尔斯伯格综合征。这些病例的显著特点是泌尿症状严重,需要专门的个体化膀胱管理策略。本病例系列旨在提高对这种新出现的临床病症的认识,这种病症在从COVID-19康复的儿童中可能未得到充分诊断。儿科医生、全科医生和泌尿科医生在考虑将NLUTD作为出现新的或不明原因泌尿症状儿童的潜在诊断时应保持警惕。早期诊断和及时管理对于有效解决这些症状以及预防潜在并发症(如不可逆的上尿路损害或长期膀胱功能障碍)至关重要。

结论

有必要进行进一步研究以阐明COVID-19后NLUTD的病理生理机制。此外,需要进行长期随访研究,以更好地了解这种病症在儿科人群中的自然病程和影响,并制定有效的预防和治疗策略。