Mosiello Giovanni, Barone Giulia, Pellegrino Chiara, Barretta Ida, Sollini Maria Laura, Castelli Enrico, Bella Gessica Della, Deanesi Noemi, Paolella Gaia, Capitanucci Maria Luisa
Division of Neuro-Urology, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare IRCCS, Rome, 00165 Italy.
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), School of Medicine, University of Genoa, Genoa, 16132 Italy.
Bladder (San Franc). 2025 Jan 10;11(4):e21200024. doi: 10.14440/bladder.2024.0043. eCollection 2024.
Among the numerous complications associated with post-coronavirus disease 2019 (COVID-19) syndrome, neurogenic lower urinary tract dysfunction (NLUTD) has been rarely reported, particularly in the pediatric population.
This report presented three pediatric cases of NLUTD that developed following severe acute respiratory syndrome coronavirus 2 infection, with clinical features resembling Elsberg syndrome. These cases were notable for the severity of their urinary symptoms, which required specialized and individualized bladder management strategies. This case series aims to raise awareness of this emerging clinical condition, which may be underdiagnosed in children recovering from COVID-19. Pediatricians, general practitioners, and urologists should be vigilant in considering NLUTD as a potential diagnosis in children presenting with new or unexplained urinary symptoms. Early diagnosis and timely management are crucial to address these symptoms effectively and prevent potential complications, such as irreversible upper urinary tract damage or long-term bladder dysfunction.
Further investigations are warranted to clarify the pathophysiological mechanisms underlying post-COVID-19 NLUTD. Moreover, long-term follow-up studies are needed to better understand the natural history and implications of this condition in the pediatric population, as well as to develop effective strategies for prevention and treatment.
在与2019冠状病毒病(COVID-19)综合征相关的众多并发症中,神经源性下尿路功能障碍(NLUTD)鲜有报道,尤其是在儿科人群中。
本报告介绍了3例严重急性呼吸综合征冠状病毒2感染后发生的儿科NLUTD病例,其临床特征类似于埃尔斯伯格综合征。这些病例的显著特点是泌尿症状严重,需要专门的个体化膀胱管理策略。本病例系列旨在提高对这种新出现的临床病症的认识,这种病症在从COVID-19康复的儿童中可能未得到充分诊断。儿科医生、全科医生和泌尿科医生在考虑将NLUTD作为出现新的或不明原因泌尿症状儿童的潜在诊断时应保持警惕。早期诊断和及时管理对于有效解决这些症状以及预防潜在并发症(如不可逆的上尿路损害或长期膀胱功能障碍)至关重要。
有必要进行进一步研究以阐明COVID-19后NLUTD的病理生理机制。此外,需要进行长期随访研究,以更好地了解这种病症在儿科人群中的自然病程和影响,并制定有效的预防和治疗策略。