Wang Xin-Da, Li Chaoya, Hu Jia, Cao Fen, Zhu Li, Zhu Yongzhi, Wen Zhongzheng, Liu Jun
Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan, China.
Hunan University of Medicine General Hospital, Huaihua, China.
Front Pharmacol. 2025 Jan 29;16:1534479. doi: 10.3389/fphar.2025.1534479. eCollection 2025.
Coronary artery disease (CAD) is the leading cause of death worldwide, and inflammation is a significant factor in its development. While the hemoglobin-to-red blood cell distribution width ratio (HRR), an indicator of inflammation, has been linked to various diseases, its association with CAD is not well established.
We conducted an analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018. After excluding participants due to age, missing data, and potential confounding factors, 6,881 individuals were included in our study. CAD was identified through self-reported questionnaires, and HRR was determined from laboratory measurements. We controlled for factors such as hypertension, waist circumference, systolic blood pressure, fasting plasma glucose, and others in our logistic regression analysis to explore the relationship between HRR and CAD.
We found that higher HRR levels were associated with a lower risk of CAD. In our fully adjusted model, the odds ratios for CAD for the second, third, and fourth quartiles of HRR were 0.38, 0.42, and 0.51, respectively, compared to the first quartile (P < 0.001). An increase in HRR by one unit was associated with a 49% decrease in the likelihood of CAD. Furthermore, linear regression models indicated a 74% reduction in CAD risk for each one-unit increase in HRR (P = 0.0002). There was a notable threshold at HRR 1.02; beyond this point, each unit increase in HRR was associated with a 91% decrease in CAD odds. This suggests that for individuals with an HRR above 1.02, strategies to increase body water content and reduce blood viscosity could potentially lower their risk of developing CAD.
Our study revealed an inverse linear relationship between HRR and CAD risk, indicating that HRR may serve as a protective factor against CAD.
冠状动脉疾病（CAD）是全球首要的死亡原因，炎症是其发展的一个重要因素。虽然血红蛋白与红细胞分布宽度比值（HRR）作为一种炎症指标，已与多种疾病相关联，但其与CAD的关联尚未完全明确。
我们使用了2011年至2018年美国国家健康与营养检查调查（NHANES）的数据进行分析。在排除因年龄、数据缺失和潜在混杂因素的参与者后，共有6881人纳入我们的研究。通过自我报告问卷确定CAD，并从实验室测量中确定HRR。我们在逻辑回归分析中控制了高血压、腰围、收缩压、空腹血糖等因素，以探讨HRR与CAD之间的关系。
我们发现较高的HRR水平与较低的CAD风险相关。在我们的完全调整模型中，与第一四分位数相比，HRR第二、第三和第四四分位数的CAD比值比分别为0.38、0.42和0.51（P < 0.001）。HRR每增加一个单位，CAD发生可能性降低49%。此外，线性回归模型表明，HRR每增加一个单位，CAD风险降低74%（P = 0.0002）。在HRR为1.02时存在一个显著阈值；超过这一点，HRR每增加一个单位，CAD比值降低91%。这表明对于HRR高于1.02的个体，增加身体含水量和降低血液粘度的策略可能会降低他们患CAD的风险。
我们的研究揭示了HRR与CAD风险之间存在反向线性关系，表明HRR可能是预防CAD的一个保护因素。
