氧化平衡评分、全身炎症反应指数与心血管疾病风险之间的关联：基于2007 - 2018年美国国家健康与营养检查调查（NHANES）数据的横断面分析

Association between oxidative balance score, systemic inflammatory response index, and cardiovascular disease risk: a cross-sectional analysis based on NHANES 2007-2018 data.

作者信息

Chen Kai, Li Senlin, Xie Zhipeng, Liu Yingjian, Li Yangchen, Mai Jinxia, Lai Chengyang, Wu Qili, Zhong Shilong

机构信息

School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.

Department of Pharmacy, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

出版信息

Front Nutr. 2024 Jun 5;11:1374992. doi: 10.3389/fnut.2024.1374992. eCollection 2024.

DOI:10.3389/fnut.2024.1374992

PMID:38899319

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11186475/

Abstract

BACKGROUND

There is limited research on the relationship between Systemic Oxidative Stress (SOS) status and inflammatory indices. Adding onto existing literature, this study aimed to examine the association between dietary Oxidative Balance Score (OBS) and lifestyle OBS (which make up the overall OBS), and Cardiovascular Disease (CVD) prevalence at different Systemic Immune Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI) levels.

METHODS

This study involved 9,451 subjects selected from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. The OBS comprised 20 dietary and lifestyle factors. Statistical methods included Weighted Linear Regression Analysis (WLRA), Logistic Regression Analysis (LRA), Sensitivity Analysis (SA), and Restricted Cubic Spline (RCS) analysis.

RESULTS

The multivariate WLRA revealed that OBS was significantly negatively correlated with both SII ( = -5.36, 0.001) and SIRI ( = -0.013, 0.001) levels. In SA, removing any single OBS component had no significant effect on the WLRA results of SII and SIRI. Further subgroup analyses revealed that OBS was more impactful in lowering SII in women than in men. Additionally, OBS was more significantly negatively correlated with SII and SIRI in the low-age group than in the high-age group. Moreover, RCS analysis confirmed this linear relationship. Compared to dietary OBS, lifestyle OBS exerted a more significant effect on Coronary Artery Disease (CAD) (OR: 0.794, = 0.002), hypertension (OR: 0.738, < 0.001), Congestive Heart Failure (CHF) (OR: 0.736, = 0.005), Myocardial Infarction (MI) (OR: 0.785, = 0.002), and stroke (OR: 0.807, = 0.029) prevalence. Furthermore, SIRI exhibited a significant interaction in the relationship between overall OBS, dietary OBS, and CHF ( < 0.001). On the other hand, SII had a significant interaction in the relationship between overall OBS, dietary OBS, and MI ( < 0.05).

CONCLUSION

OBS, including lifestyle and dietary OBS, were significantly negatively associated with SII and SIRI. Higher lifestyle OBS was associated with reduced risks of CAD, hypertension, CHF, MI, and stroke.

摘要

背景

关于全身氧化应激（SOS）状态与炎症指标之间关系的研究有限。本研究在现有文献基础上，旨在探讨饮食氧化平衡评分（OBS）和生活方式OBS（构成总体OBS）与不同全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）水平下的心血管疾病（CVD）患病率之间的关联。

方法

本研究纳入了从2007 - 2018年美国国家健康与营养检查调查（NHANES）中选取的9451名受试者。OBS包含20个饮食和生活方式因素。统计方法包括加权线性回归分析（WLRA）、逻辑回归分析（LRA）、敏感性分析（SA）和限制性立方样条（RCS）分析。

结果

多变量WLRA显示，OBS与SII（β = -5.36，P < 0.001）和SIRI（β = -0.013，P < 0.001）水平均呈显著负相关。在SA中，去除任何单个OBS成分对SII和SIRI的WLRA结果均无显著影响。进一步的亚组分析显示，OBS对降低女性SII的影响大于男性。此外，在低年龄组中，OBS与SII和SIRI的负相关性比高年龄组更显著。而且，RCS分析证实了这种线性关系。与饮食OBS相比，生活方式OBS对冠状动脉疾病（CAD）（OR：0.794，P = 0.002）、高血压（OR：0.738，P < 0.001）、充血性心力衰竭（CHF）（OR：0.736，P = 0.005）、心肌梗死（MI）（OR：0.785，P = 0.002）和中风（OR：0.807，P = 0.029）患病率的影响更显著。此外，SIRI在总体OBS、饮食OBS与CHF的关系中表现出显著的交互作用（P < 0.001）。另一方面，SII在总体OBS、饮食OBS与MI的关系中存在显著的交互作用（P < 0.05）。