Mohamad Javier R, Prijanto Stephanie Angela, Yora Vallexa Septina, Yuliana Eka Pratiwi Desak Gede, Lilhawa Ditsi Errini Sabilla, Adelia Bella, Tansuri Verika Christabela, Wijaya Hendry, Caecarma Georaldhy Yussufy, Damayanti Intan Trikumala, Ramadhanti Anisa, Rahmaputri Atika, Albab Chabib Fachry, Ferdian Afif, Farabi Fatih, Ayu Fadila Risang, Ika Regina Maharani Ni Putu, Arifin Andika Prasetyo, Herwanto Eko Setyo, A Saidah Rahmat, Arviana Safira Dita, Lathifah Syifa Nur, Yulinar Nanda Rizki, Safitri Laksmitha Saktiono, Adnani Basyar, Fazrian Danu M Rizki, Naomi Natasya, Deria Dayu Dwi, Syifa Aulia, Andana Panca, Prasetya Adrian, Agfata Fachira Rachel, Margaretha Magistra Cylvia, Indrasto Subandono Bambang, Nufus Hayatun, Chandrawati Pertiwi Febriana, Prasetyo Aan Dwi, Sutanto Lucky, Sander Moch Aleq
Department of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, Indonesia.
Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Front Cardiovasc Med. 2025 Jan 29;11:1505298. doi: 10.3389/fcvm.2024.1505298. eCollection 2024.
The Monkeypox Virus (MPOX) has caused a surge in viral infections, leading to the WHO recognizing it as a public health emergency of international concern. MPOX infection shares clinical similarities with smallpox but can cause complications like myocarditis, anorectal pain, ocular lesions, kidney damage, or soft tissue superinfection. The study aims to understand the characteristics of myocarditis, fixed drug eruption, and dry eye syndrome in Monkeypox patients.
This review was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions. The data was obtained from Scopus and international journal databases by conducting combined keyword searches restricted to English-language publications.
The study examined 25 cases of Monkeypox, primarily involving males aged 32.9 years and experiencing chest pain. The prognosis was generally good, with no reported death. Risk factors for infection include sexual activity, STD diagnosis, sexual encounters, and workplace exposure to orthopoxviruses. Most cases were male and involved chest pain. Myocarditis, an inflammation in the myocardium, can cause dilated cardiomyopathy, acute arrhythmia, and heart failure. The pathophysiology of myocarditis in Monkeypox patients is not yet determined due to rarity of cases.
MPOX infection presents unique complications like myocarditis, necessitating research for vaccines, antiviral drugs, and infection prevention measures. Early screening for chest pain and investigating MPXV infection's pathogenesis and clinical features are crucial for differential diagnosis during outbreaks. This systematic review can determine MPOX infection outcomes and prepare appropriate treatment for patients with complications.
猴痘病毒（MPOX）已导致病毒感染激增，致使世界卫生组织将其认定为国际关注的突发公共卫生事件。猴痘感染在临床上与天花有相似之处，但可引发如心肌炎、肛门直肠疼痛、眼部病变、肾脏损害或软组织继发感染等并发症。该研究旨在了解猴痘患者中心肌炎、固定型药疹和干眼症的特征。
本综述依据PRISMA（系统评价和Meta分析的首选报告项目）以及《Cochrane干预措施系统评价手册》进行。通过对仅限于英文出版物的联合关键词搜索，从Scopus和国际期刊数据库获取数据。
该研究检查了25例猴痘病例，主要涉及年龄为32.9岁且有胸痛症状的男性。预后总体良好，无死亡报告。感染的风险因素包括性行为、性传播疾病诊断、性接触以及工作场所接触正痘病毒。大多数病例为男性且伴有胸痛。心肌炎是心肌的炎症，可导致扩张型心肌病、急性心律失常和心力衰竭。由于病例罕见，猴痘患者心肌炎的病理生理学尚未确定。
猴痘感染会出现如心肌炎等独特的并发症，因此有必要对疫苗、抗病毒药物和感染预防措施进行研究。在疫情暴发期间，早期筛查胸痛并研究猴痘病毒感染的发病机制和临床特征对于鉴别诊断至关重要。这一系统评价能够确定猴痘感染的结果，并为有并发症的患者制定适当的治疗方案。
