Jabbari B, Bryan G E, Marsh E E, Gunderson C H
Arch Neurol. 1985 May;42(5):480-1. doi: 10.1001/archneur.1985.04060050082013.
One hundred eighty-six depressed psychiatric inpatients were seen at our institution during 1982. Forty-five of these patients were treated with tricyclic antidepressants, 32 received maprotiline hydrochloride, a tetracyclic compound, 20 received other medications, and 82 received no drug treatment. One patient in the tricyclic group (2.2%) and five patients in the maprotiline group (15.6%) developed seizures. In four patients the seizure followed the institution of maprotiline therapy by less than three weeks. These data indicate that depressed patients taking the tetracyclic drug maprotiline are at risk for developing epileptic seizures.
1982年，我们机构接待了186名患有抑郁症的精神科住院患者。其中45名患者接受了三环类抗抑郁药治疗，32名患者接受了四环化合物盐酸马普替林治疗，20名患者接受了其他药物治疗，82名患者未接受药物治疗。三环类药物组中有1名患者（2.2%）和马普替林组中有5名患者（15.6%）出现了癫痫发作。在4名患者中，癫痫发作是在开始马普替林治疗后不到三周内出现的。这些数据表明，服用四环类药物马普替林的抑郁症患者有发生癫痫发作的风险。
