抗抑郁药的安全性。
The safety of antidepressants.
作者信息
de Jonghe F, Swinkels J A
机构信息
Department of Psychiatry, University of Amsterdam, The Netherlands.
出版信息
Drugs. 1992;43 Suppl 2:40-6; discussion 46-7. doi: 10.2165/00003495-199200432-00007.
In this article, a distinction is proposed between safe and less safe antidepressants. The safety of 18 antidepressants is discussed in relation to 3 principal issues: the safety of the drug in the event of an overdose; the seriousness of its side effects; and the existence of dangerous interactions. On the basis of present information, it can be said with reasonable confidence that fluoxetine, fluvoxamine and paroxetine are safe antidepressants, and with some reservation (mainly because of hypnosedation) the same can be said of mianserin and trazodone.
本文提出了安全与安全性稍低的抗抑郁药之间的区别。文中讨论了18种抗抑郁药在三个主要方面的安全性：药物过量时的安全性；副作用的严重程度；以及是否存在危险的相互作用。根据目前的信息，可以相当有把握地说，氟西汀、氟伏沙明和帕罗西汀是安全的抗抑郁药，对于米安色林和曲唑酮，虽有所保留（主要是因为有催眠镇静作用），但也可得出同样结论。
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