David Guy, Epstein Andrew J, Giri Jay, Nathan Ashwin, Chikermane Soumya G, Ryan Michael, Thompson Christin, Clancy Seth, Gunnarsson Candace
University of Pennsylvania, Philadelphia, PA, USA.
Medicus Economics, Boston, MA, USA.
Adv Ther. 2025 Apr;42(4):1716-1728. doi: 10.1007/s12325-025-03116-8. Epub 2025 Feb 13.
This study investigates the impact of geographic and socioeconomic barriers on access to transcatheter aortic valve replacement (TAVR).
Utilizing Medicare data from the US Centers for Medicare and Medicaid Services, this study analyzed TAVR and surgical aortic valve replacement (SAVR) procedures among beneficiaries from 2017 to 2022. Geographic units were defined by 5-digit zip codes, categorized on the basis of TAVR/SAVR volume into four categories: (1) no TAVR or SAVR, (2) no-TAVR zone (SAVR present, no TAVR), (3) low-TAVR zone (TAVR/SAVR ratio ≤ 0.5), and (4) TAVR accessible (TAVR/SAVR ratio > 0.5). The differential distance index (DDI) was developed to measure travel hurdles, calculated as the difference in miles from a patient's zip code center to the treatment hospital (TAVR versus SAVR, CABG (coronary artery bypass grafting), and PCI (percutaneous coronary intervention) comparators). This study maintained a continuous access variable to model outcomes such as the ratio or volume of TAVR/SAVR and the percentage share of TAVR/AVR within each zip code over biennial periods (2017-2018, 2019-2020, 2021-2022). Covariates in the model included population density, area deprivation index (ADI), and calendar time, with an exploration of the interaction between DDI and ADI.
The analysis revealed significant geographic disparities in TAVR access across the USA, with no-TAVR zone and low-TAVR zone areas often featuring lower population densities, higher ADIs, and more rural settings. Increased travel distance (DDI) significantly correlated with lower TAVR utilization, emphasizing distance as a critical barrier. Furthermore, both ADI and DDI emerged as significant predictors of TAVR volume and share, underlining the compound effect of socioeconomic status and geographic distance on healthcare access.
This study highlights the critical role of geographic and socioeconomic barriers in accessing advanced medical treatments like TAVR. Addressing these barriers may ensure equitable healthcare distribution, guiding policymakers and providers towards more accessible healthcare solutions for all populations.
本研究调查地理和社会经济障碍对经导管主动脉瓣置换术(TAVR)可及性的影响。
利用美国医疗保险和医疗补助服务中心的医疗保险数据,本研究分析了2017年至2022年受益人群中的TAVR和外科主动脉瓣置换术(SAVR)手术情况。地理单元由五位邮政编码定义,根据TAVR/SAVR手术量分为四类:(1)无TAVR或SAVR;(2)无TAVR区域(有SAVR,无TAVR);(3)低TAVR区域(TAVR/SAVR比率≤0.5);(4)可及TAVR区域(TAVR/SAVR比率>0.5)。开发了差异距离指数(DDI)来衡量出行障碍,计算方法是从患者邮政编码中心到治疗医院(TAVR与SAVR、冠状动脉旁路移植术(CABG)和经皮冠状动脉介入治疗(PCI)对照)的英里数差异。本研究维持了一个连续的可及性变量,以对两年期(2017 - 2018年、2019 - 2020年、2021 - 2022年)内每个邮政编码内TAVR/SAVR的比率或手术量以及TAVR/AVR的百分比份额等结果进行建模。模型中的协变量包括人口密度、区域贫困指数(ADI)和日历时间,并探讨了DDI与ADI之间的相互作用。
分析显示,美国各地TAVR可及性存在显著的地理差异,无TAVR区域和低TAVR区域通常人口密度较低、ADI较高且更偏远。出行距离增加(DDI)与TAVR利用率降低显著相关,强调距离是一个关键障碍。此外,ADI和DDI均成为TAVR手术量和份额的显著预测因素,突显了社会经济地位和地理距离对医疗可及性的复合影响。
本研究强调了地理和社会经济障碍在获取TAVR等先进医疗治疗方面的关键作用。解决这些障碍可能确保医疗保健的公平分配,引导政策制定者和医疗服务提供者为所有人群提供更易获得的医疗保健解决方案。