Akhmadullina Yu R
Urals Research Center for Radiation Medicine, Federal Medical-Biological Agency of Russia, Chelyabinsk, Russia.
Bull Exp Biol Med. 2025 Jan;178(3):363-366. doi: 10.1007/s10517-025-06337-7. Epub 2025 Feb 13.
Chromosomal composition of micronuclei of phytohemagglutinin-stimulated peripheral blood T lymphocytes in women chronically exposed to radiation due to their residence in the Techa riverside settlements in the Sothern Urals (mean age 76.4±1.2 years, mean cumulative dose for the red bone marrow 1.4±0.3 Gy) was analyzed using the cytochalasin-block micronucleus assay and multicolor fluorescent in situ hybridization (mFISH). Exposed women demonstrated an increase in the number of chromosomes eliminated from cell nucleus, but the frequency of micronuclei did not differ from that in the comparison group. High variability of the frequency of micronuclei was also noted in the group of exposed women. In all the women, X-chromosome and autosomes 2, 16 were significantly more often eliminated than other chromosomes.
对居住在南乌拉尔地区捷恰河畔定居点、长期受辐射影响的女性（平均年龄76.4±1.2岁，红骨髓平均累积剂量1.4±0.3 Gy）经植物血凝素刺激的外周血T淋巴细胞微核的染色体组成，采用细胞松弛素阻断微核试验和多色荧光原位杂交（mFISH）进行分析。受辐射女性细胞核中消除的染色体数量增加，但微核频率与对照组无差异。在受辐射女性组中还发现微核频率存在高度变异性。在所有女性中，X染色体以及2号和16号常染色体比其他染色体更常被消除。
