自然流产率、妊娠次数与神经管缺陷

Spontaneous abortion rates, gravidity and neural tube defects.

作者信息

James W H

出版信息

Early Hum Dev. 1978 Sep;2(3):291-5. doi: 10.1016/0378-3782(78)90032-4.

Abstract

Kline and her co-workers [20, 21] suggest that spontaneous abortions show no overall gravidity effect. However, spontaneous abortions seem to show a negative gravidity effect in some sibships (those containing an infant affected by anencephaly or spina bifida) [22]. It is inferred that there is a heterogeneity among spontaneous abortion sibships, and that there are other sibships in which spontaneous abortions show a positive gravidity effect (perhaps as a result of e.g. iso-immunization).

摘要

克莱因及其同事[20, 21]指出，自然流产总体上不存在妊娠次数效应。然而，在一些同胞组中（那些包含受无脑儿或脊柱裂影响婴儿的同胞组），自然流产似乎呈现出负妊娠次数效应[22]。据推断，自然流产同胞组之间存在异质性，并且存在其他一些同胞组，其中自然流产呈现出正妊娠次数效应（可能例如是由于同种免疫的结果）。