一项比较在家用漂白技术中使用脱敏剂疗效的三盲随机临床试验。

A TRIPLE-BLIND RANDOMIZED CLINICAL TRIAL COMPARING THE EFFICACY OF A DESENSITIZING AGENT USED WITH AN AT-HOME BLEACHING TECHNIQUE.

作者信息

Pereira-Lores Patricia, Alonso DE LA Peña Víctor, Gancedo-Gancedo Tania, Villasenín-Sánchez Carolina, Bello-Castro Alba, Martín-Biedma Benjamín, Castelo-Baz Pablo

机构信息

Endodontics and Restorative Dentistry Unit, School of Medicine and Dentistry, Universidade de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.

出版信息

J Evid Based Dent Pract. 2025 Mar;25(1):102079. doi: 10.1016/j.jebdp.2024.102079. Epub 2024 Dec 9.

DOI:10.1016/j.jebdp.2024.102079

PMID:39947775

Abstract

PURPOSE

The aim of this study was to determine whether a sustained-release desensitizing gel containing 3% potassium nitrate and 0.11% fluoride ion reduces the risk of tooth sensitivity without compromising the effectiveness of bleaching treatment.

METHODS

Thirty-two patients were randomly assigned to 2 experimental groups: desensitizing gel and placebo. The desensitizing gel or placebo was applied for 30 minutes prior to the at-home vital bleaching gel application. A nightguard dental bleaching treatment (NGVB) using a 16% carbamide peroxide gel was performed for 6 hours over a 3-week period. Patients recorded their tooth sensitivity daily using a 5-point Numeric Rating Scale (NRS). Whiteness index measurements were obtained using a dental spectrophotometer on the upper canines (right and left).

RESULTS

The overall risk of sensitivity was 37.5% in the desensitizing gel group compared to 87.5% in the placebo group, yielding a relative risk of 0.42 (95% CI 0.22-0.82), showing a statistically significant difference between the groups (P < .05). During the first week, patients in the placebo group exhibited a higher risk of experiencing mild sensitivity. However, no statistically significant differences in sensitivity intensity were observed overall or during the second and third weeks (P > .05). Regarding color change, the mean difference between groups in the first week was 5.25 (-0.22 to 10.71), in the second week 4.25 (-2.56 to 11.02), and in the third week 2.55(-4.11 to 9.22). No statistically significant differences were found between the groups at any time point (P > .05).

CONCLUSIONS

The use of a sustained-release desensitizing gel containing 3% potassium nitrate and 0.11% fluoride ion for 30 minutes prior to the bleaching agent effectively reduced sensitivity during at-home bleaching procedures. Furthermore, the desensitizing gel did not impact the effectiveness of the at-home bleaching treatment.

摘要

目的

本研究旨在确定含有3%硝酸钾和0.11%氟离子的缓释脱敏凝胶在不影响漂白治疗效果的情况下，是否能降低牙齿敏感的风险。

方法

32例患者被随机分为2个实验组：脱敏凝胶组和安慰剂组。在家庭使用活髓漂白凝胶之前，先涂抹脱敏凝胶或安慰剂30分钟。使用16%过氧化脲凝胶进行夜间护齿漂白治疗（NGVB），为期3周，每次6小时。患者每天使用5分数字评定量表（NRS）记录牙齿敏感度。使用牙科分光光度计对上颌尖牙（左右）进行白度指数测量。

结果

脱敏凝胶组的总体敏感风险为37.5%，而安慰剂组为87.5%，相对风险为0.42（95%CI 0.22 - 0.82），两组间差异有统计学意义（P < 0.05）。在第一周，安慰剂组患者出现轻度敏感的风险更高。然而，总体上以及在第二周和第三周，敏感强度方面未观察到统计学显著差异（P > 0.05）。关于颜色变化，第一周组间平均差异为5.25（-0.22至10.71），第二周为4.25（-2.56至11.02），第三周为2.55（-4.11至9.22）。在任何时间点，两组间均未发现统计学显著差异（P > 0.05）。