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巴西香脂油树脂对牙齿漂白后敏感性控制及颜色变化的影响:一项随机临床试验。

Effect of copaiba oil-resin on dental sensitivity control and color change after bleaching: A randomized clinical trial.

作者信息

Gil Giovana Solheid, Xavier Gabriela Monteiro Barbosa, de Almeida Canelas Caio Augusto, Lima Rafael Rodrigues, Rodrigues Ana Paula Drummond, Araújo Jesuina Lamartine Nogueira, Passos Marcele Fonseca, Silva Cecy Martins

机构信息

Federal University of Pará (Biomaterials Laboratory- LABIOMAT), Belém, (Pará), Brasil- Augusto Corrêa, 1 - Guamá, Belém, PA, 66075-110, Brazil.

Federal University of Pará (Laboratory of Amazon Oil), Belém, Pará, Brazil - Augusto Corrêa, 1 - Guamá, Belém, PA, 66075-110, Brazil.

出版信息

Clin Oral Investig. 2025 May 13;29(6):296. doi: 10.1007/s00784-025-06375-5.

Abstract

OBJECTIVE

This randomized clinical trial evaluated a copaiba oil-based gel in controlling dental sensitivity (DS) and color change after dental bleaching.

MATERIALS AND METHODS

Seventy-five volunteers were randomized into three groups (n = 25): GC (placebo gel - negative control); GKF2% (gel of 5% potassium nitrate and 2% sodium fluoride - positive control); and GCO (copaiba oil gel). Three bleaching sessions were performed using 35% hydrogen peroxide (HP 35%), with 7-day intervals. The desensitizing gels were applied for 10 min in each group. The DS was evaluated over 21 days using a visual analog scale (VAS). Color evaluation was done with a spectrophotometer before and after bleaching using the CIEDE2000. The DS was assessed between groups (Kruskal-Wallis test) and within groups (Friedman test). The color change was analyzed using one-way ANOVA and Tukey's test.

RESULTS

GCO and GKF2% showed the lowest sensitivity values, with no significant difference (p < 0.05). In the intragroup analysis, GCO and GKF2% showed no differences across the three whitening sessions (p = 0.974, p = 0.213, p = 0.143, respectively). Conversely, GC exhibited an increase in DS after the last session (p = 0.035). All groups showed color change, without statistically significant differences between the groups (p = 0.725).

CONCLUSION

The copaiba gel reduced dental sensitivity after treatment with 35% hydrogen peroxide, without affecting the bleaching effectiveness.

CLINICAL RELEVANCE

The topical application of the experimental copaiba oil gel was effective in reducing dental sensitivity after bleaching with 35% hydrogen peroxide.

摘要

目的

本随机临床试验评估了一种基于 Copaiba 油的凝胶在控制牙齿漂白后的牙齿敏感(DS)和颜色变化方面的效果。

材料与方法

75 名志愿者被随机分为三组(n = 25):GC(安慰剂凝胶 - 阴性对照);GKF2%(含 5%硝酸钾和 2%氟化钠的凝胶 - 阳性对照);以及 GCO(Copaiba 油凝胶)。使用 35%过氧化氢(HP 35%)进行三次漂白疗程,间隔 7 天。每组脱敏凝胶涂抹 10 分钟。使用视觉模拟量表(VAS)在 21 天内评估 DS。使用 CIEDE2000 在漂白前后用分光光度计进行颜色评估。组间(Kruskal-Wallis 检验)和组内(Friedman 检验)评估 DS。使用单因素方差分析和 Tukey 检验分析颜色变化。

结果

GCO 和 GKF2%显示出最低的敏感值,无显著差异(p < 0.05)。在组内分析中,GCO 和 GKF2%在三次美白疗程中无差异(分别为 p = 0.974、p = 0.213、p = 0.143)。相反,GC 在最后一次疗程后 DS 有所增加(p = 0.035)。所有组均出现颜色变化,组间无统计学显著差异(p = 0.725)。

结论

Copaiba 凝胶在用 35%过氧化氢治疗后可降低牙齿敏感性,且不影响漂白效果。

临床意义

实验性 Copaiba 油凝胶的局部应用在 35%过氧化氢漂白后有效降低牙齿敏感性。

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