Ethnic difference in drug metabolism: debrisoquine 4-hydroxylation in Caucasians and Orientals.
作者信息
Kalow W, Otton S V, Kadar D, Endrenyi L, Inaba T
出版信息
Can J Physiol Pharmacol. 1980 Sep;58(9):1142-4. doi: 10.1139/y80-173.
DOI:10.1139/y80-173
PMID:7459706
Abstract
The extent to which debrisoquine (D) is metabolized to 4-hydroxydebrisoquine (4OHD) was found to be influenced by the ethnic origin of the subjects. Following ingestion of 20 mg of debrisoquine sulfate, Orientals excreted, on the average, significantly more D and less 4OHD in 0- to 8-h urine than Caucasians; however, the sums of D + 4OHD did not differ.
摘要
Zotero 插件