使用H17 E2单克隆抗体检测法，将胎盘碱性磷酸酶作为精原细胞瘤的肿瘤标志物。
Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay.
作者信息
Horwich A, Tucker D F, Peckham M J
出版信息
Br J Cancer. 1985 May;51(5):625-9. doi: 10.1038/bjc.1985.94.
Abstract
Serum samples from 62 patients with seminoma were assayed for placental alkaline phosphatase-like activity using the monoclonal antibody H17 E2, in order to evaluate its utility as a serum tumour marker. Fifteen of 16 patients (94%) with active seminoma had elevated serum PLAP levels. Sixteen of 46 (35%) of patients considered to be in remission had elevated PLAP levels (false positive rate 35%). Fifteen false positive results were considered attributable to concomitant smoking, and if these patients are excluded, only one false positive case was detected. In 7 out of 7 patients sequential PLAP assays reflected clinical response to treatment.
摘要
使用单克隆抗体H17 E2对62例精原细胞瘤患者的血清样本进行胎盘碱性磷酸酶样活性检测，以评估其作为血清肿瘤标志物的效用。16例活动性精原细胞瘤患者中有15例（94%）血清PLAP水平升高。46例处于缓解期的患者中有16例（35%）PLAP水平升高（假阳性率35%）。15例假阳性结果被认为归因于同时吸烟，如果排除这些患者，仅检测到1例假阳性病例。7例患者中有7例连续的PLAP检测反映了对治疗的临床反应。
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本文引用的文献
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