Phulari Rashmi Gs, Solanki Bharvi
Department of Oral and Maxillofacial Pathology and Microbiology, Manubhai Patel Dental College and Hospital and Oral Research Institute, Vishwajyoti Ashram, Near Vidyakunj School, Maunjmauda, Vadodara, Gujarat, India.
J Oral Maxillofac Pathol. 2024 Oct-Dec;28(4):641-650. doi: 10.4103/jomfp.jomfp_327_22. Epub 2024 Dec 31.
Head and Neck squamous cell carcinoma is an immunosuppressive state. HNSCC evades immune responses through multiple resistance mechanisms. Because of better understanding of interaction between tumour microenvironment and immune regulators, there is increasing interest in role of immunotherapy as a treatment modality of HNSCC. Many clinical trials have been performed using checkpoint inhibitors, as monotherapies and combination therapies. Immune checkpoint molecule, programmed cell death 1 (PD-1) has shown promising results as a treatment of Recurrent and Metastatic HNSCC. This review discusses immune checkpoint molecules, their functional mechanisms, role of immunotherapy as a monotherapies and combination therapy for better treatment and prognosis of HNSCC patients.
头颈部鳞状细胞癌处于免疫抑制状态。头颈部鳞状细胞癌通过多种抵抗机制逃避免疫反应。由于对肿瘤微环境与免疫调节因子之间的相互作用有了更深入的了解，人们对免疫疗法作为头颈部鳞状细胞癌的一种治疗方式的作用越来越感兴趣。已经进行了许多使用检查点抑制剂的临床试验，包括单药治疗和联合治疗。免疫检查点分子程序性细胞死亡蛋白1（PD-1）作为复发性和转移性头颈部鳞状细胞癌的一种治疗方法已显示出有前景的结果。这篇综述讨论了免疫检查点分子、它们的功能机制、免疫疗法作为单药治疗和联合治疗对头颈部鳞状细胞癌患者更好的治疗和预后的作用。
