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脑脊液诊断管理干预对检查数量、住院时间、抗生素处方及费用的影响。

Impact of a cerebrospinal fluid diagnostic stewardship intervention on quantity of tests, length of stay, antibiotic prescriptions, and cost.

作者信息

Pathak Aaron, Shay Sabra, Lasco Todd, Al Mohajer Mayar

机构信息

School of Medicine, Baylor College of Medicine, Houston, TX, USA.

Department of Clinical Intelligence, Premier Inc., Charlotte, NC, USA.

出版信息

Antimicrob Steward Healthc Epidemiol. 2025 Feb 11;5(1):e35. doi: 10.1017/ash.2025.17. eCollection 2025.

Abstract

Redundant and low-value cerebrospinal fluid analysis for suspected meningitis can increase costs and antimicrobial use. Our diagnostic stewardship intervention limited available infectious disease cerebrospinal fluid assays to seven common tests, including a multiplex polymerase chain reaction panel. There was no significant difference in the cost of testing or clinical outcomes.

摘要

对疑似脑膜炎进行多余且低价值的脑脊液分析会增加成本和抗菌药物的使用。我们的诊断管理干预措施将可用的感染性疾病脑脊液检测项目限制为七项常见检测,包括一个多重聚合酶链反应检测板。检测成本或临床结果没有显著差异。

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本文引用的文献

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The impact of the FilmArray meningitis/encephalitis panel on empiric antibiotic prescriptions in patients with suspected community-acquired meningitis.
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Progress and Challenges in Bacterial Meningitis: A Review.
JAMA. 2022 Dec 6;328(21):2147-2154. doi: 10.1001/jama.2022.20521.
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Multiplex Polymerase Chain Reaction Testing to Diagnose Central Nervous System Infections-A Doubled-Edged Sword.
J Pediatric Infect Dis Soc. 2022 Apr 30;11(4):124-125. doi: 10.1093/jpids/piab131.
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Evaluation of the selection of cerebrospinal fluid testing in suspected meningitis and encephalitis.
Diagn Microbiol Infect Dis. 2022 Jan;102(1):115571. doi: 10.1016/j.diagmicrobio.2021.115571. Epub 2021 Oct 11.
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Diagnostic Stewardship-Leveraging the Laboratory to Improve Antimicrobial Use.
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