Henriksson P, Hamberg M, Diczfalusy U
Biochim Biophys Acta. 1985 Apr 25;834(2):272-4. doi: 10.1016/0005-2760(85)90166-3.
Atherosclerosis was induced in New Zealand White rabbits through cholesterol feeding. Aortae were taken out from treated animals and incubated with arachidonic acid. Aortae from cholesterol-fed animals converted arachidonic acid into 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE). This conversion was not seen in aortae from control animals. The immediate precursor of 15-HETE, 15-HPETE, is an inhibitor of prostacyclin synthetase and might hamper prostacyclin production.
通过喂食胆固醇在新西兰白兔中诱发动脉粥样硬化。从经处理的动物身上取出主动脉，并用花生四烯酸进行孵育。喂食胆固醇的动物的主动脉将花生四烯酸转化为15-羟基-5,8,11,13-二十碳四烯酸（15-HETE）。在对照动物的主动脉中未观察到这种转化。15-HETE的直接前体15-HPETE是前列环素合成酶的抑制剂，可能会阻碍前列环素的产生。
