Thanasarnaksorn Wilai, Limsuchaiwat Nathamon, Sirithanabadeekul Punyaphat, Charoensuksira Sasin, Suwanchinda Atchima, Meephansan Jitlada
Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathum Thani, 12120, Thailand.
Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Arch Dermatol Res. 2025 Feb 14;317(1):399. doi: 10.1007/s00403-025-03908-6.
Androgenetic alopecia (AGA) is a highly prevalent condition that poses a significant challenge to quality of life, yet the US Food and Drug Administration-approved treatments remain limited. Polynucleotides (PN) stimulate tissue regeneration by reducing inflammation, activation of growth factors and accelerating angiogenesis, which are vital for hair regrowth. This study aimed to assess the efficacy of PN in promoting hair regrowth by measuring changes in hair diameter and density in patients with AGA. This prospective study evaluated 28 patients with AGA who received four injection of DOT™ PN (DNA Fragment Optimizing Technology Polynucleotides) at four-week intervals. Hair diameter and density were quantitatively assessed using dermoscopic analysis. Treatment efficacy was also evaluated using patient and dermatologist satisfaction survey. Both hair diameter and density showed significant improvement, with hair diameter increased notably one month post-treatment and continuing to rise throughout the study. Total hair density improvements were evident from one months post-treatment onwards. Additionally, the dermatologist's assessment indicated stabilization in 60.7% of cases, while the patient assessment score indicated improvement in 82.1% of cases, with no serious side effects. This study demonstrates that PN effectively promotes hair regrowth in AGA patients. This is likely due to increased angiogenesis and anti-apoptotic effects. PN offers a promising new alternative for patients who have not responded to traditional treatments.
雄激素性脱发（AGA）是一种非常普遍的病症，对生活质量构成重大挑战，然而美国食品药品监督管理局批准的治疗方法仍然有限。多核苷酸（PN）通过减轻炎症、激活生长因子和加速血管生成来刺激组织再生，而这些对于头发生长至关重要。本研究旨在通过测量AGA患者的头发直径和密度变化来评估PN促进头发生长的疗效。这项前瞻性研究评估了28例AGA患者，他们每隔四周接受四次DOT™ PN（DNA片段优化技术多核苷酸）注射。使用皮肤镜分析对头发直径和密度进行定量评估。还通过患者和皮肤科医生满意度调查来评估治疗效果。头发直径和密度均有显著改善，治疗后一个月头发直径显著增加，并在整个研究过程中持续上升。从治疗后一个月起，总头发密度明显提高。此外，皮肤科医生的评估表明60.7%的病例病情稳定，而患者评估得分表明82.1%的病例有所改善，且无严重副作用。本研究表明PN能有效促进AGA患者的头发生长。这可能是由于血管生成增加和抗凋亡作用。PN为对传统治疗无反应的患者提供了一种有前景的新选择。
