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毛发再生疗法：脂肪来源干细胞的应用。

Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells.

机构信息

Cherry-Blossom Plastic and Regenerative Surgery, Tokyo. Japan.

Department of Plastic Surgery, Kyorin University School of Medicine, Tokyo. Japan.

出版信息

Curr Stem Cell Res Ther. 2017;12(7):531-534. doi: 10.2174/1574888X12666170522114307.

DOI:10.2174/1574888X12666170522114307
PMID:28530535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6327114/
Abstract

BACKGROUND

Adipose-derived stem cells secrete various cytokines that promote hair growth.

OBJECTIVE

To describe our experience of hair regeneration therapy using adipose-derived stem cellconditioned medium.

RESULTS

We performed the hair regeneration therapy in numerous Japanese patients and reported good results. We described characteristics of the commercialized conditioned medium, treatment methods, and future directions.

CONCLUSION

Treatment using adipose-derived stem cell-conditioned medium is highly effective and may represent a new therapy for alopecia.

摘要

背景

脂肪来源的干细胞分泌各种细胞因子，促进头发生长。

目的

描述我们使用脂肪来源的干细胞条件培养基进行毛发再生治疗的经验。

结果

我们在许多日本患者中进行了毛发再生治疗，并报告了良好的结果。我们描述了商业化的条件培养基的特点、治疗方法和未来方向。

结论

使用脂肪来源的干细胞条件培养基进行治疗非常有效，可能代表了一种治疗脱发的新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/91ad2231cbc1/CSCR-12-531_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/9961cb954bff/CSCR-12-531_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/7e624838b17c/CSCR-12-531_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/2c88597569e8/CSCR-12-531_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/54f974bc30a6/CSCR-12-531_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/91ad2231cbc1/CSCR-12-531_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/9961cb954bff/CSCR-12-531_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/7e624838b17c/CSCR-12-531_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/2c88597569e8/CSCR-12-531_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/54f974bc30a6/CSCR-12-531_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/6327114/91ad2231cbc1/CSCR-12-531_F5.jpg

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Eplasty. 2015 Mar 26;15:e10. eCollection 2015.
2
Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men.基于证据的（S3）女性和男性雄激素性脱发治疗指南。
J Dtsch Dermatol Ges. 2011 Oct;9 Suppl 6:S1-57. doi: 10.1111/j.1610-0379.2011.07802.x.
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Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling.
氧化应激激活移植的脂肪来源干细胞，在脱发治疗中发挥抗氧化作用。
Redox Rep. 2025 Dec;30(1):2503128. doi: 10.1080/13510002.2025.2503128. Epub 2025 Jun 6.
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Safety assessment of multiple systemic administration of human mesenchymal stem cell-conditioned medium for various chronic diseases.人骨髓间充质干细胞条件培养基多次全身给药用于多种慢性疾病的安全性评估。
PLoS One. 2025 May 6;20(5):e0322497. doi: 10.1371/journal.pone.0322497. eCollection 2025.
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A Pilot Randomized Controlled Trial (RCT) Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia.一项评估含外泌体植物提取物配方治疗男性脱发疗效的随机对照试验（RCT）初步研究
Life (Basel). 2025 Mar 20;15(3):500. doi: 10.3390/life15030500.
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Secretome from HMGB1 Box A-over-expressing Adipose-derived Stem Cells Shows Potential for Skin Rejuvenation by Senescence Reversal in PM2.5-induced Senescence Cells Stem Cell Induction.高迁移率族蛋白B1（HMGB1）A盒过表达脂肪干细胞的分泌组通过逆转PM2.5诱导的衰老细胞中的细胞衰老显示出皮肤年轻化的潜力 干细胞诱导。
In Vivo. 2025 Mar-Apr;39(2):766-777. doi: 10.21873/invivo.13881.
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Polynucleotides as a novel therapeutic approach in androgenetic alopecia: an analysis of effectiveness and safety.多核苷酸作为雄激素性脱发的一种新型治疗方法：有效性和安全性分析
Arch Dermatol Res. 2025 Feb 14;317(1):399. doi: 10.1007/s00403-025-03908-6.
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Adipose-derived stem cell conditioned medium for hair regeneration therapy in alopecia: a review of literature.脂肪来源干细胞条件培养液在脱发症的毛发再生治疗中的应用：文献综述。
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Clinical and preclinical approach in AGA treatment: a review of current and new therapies in the regenerative field.AGA 治疗的临床和临床前方法：再生领域现有和新疗法的综述。
Stem Cell Res Ther. 2024 Aug 15;15(1):260. doi: 10.1186/s13287-024-03801-5.
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Promotion of hair growth by a conditioned medium from human umbilical cord mesenchymal stem cells cultivated in a 3D scaffold of gelatin sponge.三维支架中海藻酸钠-明胶共培养的人脐带间充质干细胞条件培养液促进毛发生长。
Eur J Med Res. 2024 May 4;29(1):270. doi: 10.1186/s40001-024-01830-7.
脂肪细胞谱系细胞有助于皮肤干细胞龛，以驱动毛发周期。
Cell. 2011 Sep 2;146(5):761-71. doi: 10.1016/j.cell.2011.07.019.
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Efficacy and safety of finasteride therapy for androgenetic alopecia: a systematic review.非那雄胺治疗雄激素性脱发的疗效与安全性：一项系统评价。
Arch Dermatol. 2010 Oct;146(10):1141-50. doi: 10.1001/archdermatol.2010.256.
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Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion.缺氧增强脂肪来源干细胞条件培养基刺激的毛发生长：生长因子分泌增加的证据。
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Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF.缺氧增强脂肪干细胞的伤口愈合功能：干细胞增殖增加以及血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）上调。
Wound Repair Regen. 2009 Jul-Aug;17(4):540-7. doi: 10.1111/j.1524-475X.2009.00499.x.
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Alopecia secondary to mesotherapy.中胚层疗法继发的脱发
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Skin aging.皮肤老化。
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