Department of Dermatology, Kyunghee University Hospital at Gangdong, Seoul, Republic of Korea.
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
J Dermatolog Treat. 2022 Feb;33(1):254-260. doi: 10.1080/09546634.2020.1748857. Epub 2020 Apr 6.
Filler injection has become an extremely popular method for facial skin rejuvenation, including the periorbital area. In the recent years, new polynucleotide (PN)-containing filler products have been used for esthetic purposes.
We aimed to investigate the efficacy and safety of PN filler injection in the periorbital area.
PATIENTS/METHODS: A total of 27 subjects were enrolled in this randomized, pair-matched, and active-controlled study. Each subject received filler injections thrice with two-week intervals, with a PN filler injection on one side and a non-crosslinked hyaluronic acid (HA) filler injection on the contralateral side of the periorbital area.
Improvements in the visual analog scale and global esthetic improvement scale scores were not significantly different between the PN and HA groups. The improvement rates of skin elasticity and hydration decreased over time in both groups, with the PN group showing a higher improvement rate. The improvement rates of roughness and pore volume were higher in the PN group than in the HA group. The improvement rate of dermal density was not significantly different between the groups. No serious adverse events were reported.
The PN filler injection is effective and safe for periorbital rejuvenation.
填充物注射已成为一种非常流行的面部皮肤年轻化方法，包括眶周区域。近年来，新的含多核苷酸（PN）的填充物产品已被用于美容目的。
我们旨在研究 PN 填充物在眶周区域的疗效和安全性。
患者/方法：共有 27 名受试者参加了这项随机、配对、阳性对照研究。每位受试者接受了三次每两周一次的填充物注射，在眶周区域的一侧进行 PN 填充物注射，另一侧进行非交联透明质酸（HA）填充物注射。
PN 组和 HA 组在视觉模拟量表和整体美学改善量表评分方面的改善无显著差异。两组的皮肤弹性和水分改善率随时间推移而降低，PN 组的改善率更高。粗糙度和毛孔容积的改善率在 PN 组高于 HA 组。真皮密度的改善率在两组之间无显著差异。未报告严重不良事件。
PN 填充物注射对眶周年轻化是有效且安全的。
