Soto E A, Tureck R W, Strauss J F
Biol Reprod. 1985 Apr;32(3):541-5. doi: 10.1095/biolreprod32.3.541.
Concentrations of human prolactin (hPrl) greater than or equal to 600 ng/ml produced inhibition of progestin production in cultures of granulosa cells pooled from follicles of women stimulated with clomiphene citrate-human chorionic gonadotropin (hCG). However, cells collected from follicles of human menopausal gonadotropin (HMG)-hCG-treated patients did not demonstrate a significant reduction in progestin secretion in response to hPrl. We conclude that high concentrations of hPrl can result in inhibition of steroidogenesis, but the expression of the inhibitory effects of Prl depends upon the hormonal treatments used to stimulate follicular growth.
在使用枸橼酸氯米芬 - 人绒毛膜促性腺激素（hCG）刺激的女性卵泡中收集的颗粒细胞培养物中，人催乳素（hPrl）浓度大于或等于600 ng/ml会抑制孕激素的产生。然而，从接受人绝经期促性腺激素（HMG）-hCG治疗的患者卵泡中收集的细胞，对hPrl刺激并未显示出孕激素分泌的显著减少。我们得出结论，高浓度的hPrl可导致类固醇生成受到抑制，但Prl抑制作用的表现取决于用于刺激卵泡生长的激素治疗。
