Morris A H, Crapo R O
Bull Eur Physiopathol Respir. 1985 Mar-Apr;21(2):183-9.
The transfer factor (TLCOsb) is currently widely used as a lung function test. Although the test maneuver itself is well described and uniformly approached by most workers, the computation technique varies considerably. Significant changes in the TLCOsb are induced by correcting for: blood hemoglobin concentration [Hb], apparatus and anatomic dead space (VD), alveolar gas sample dead space (VDbag), carboxyhemoglobin concentration (COHb), alveolar carbon dioxide fraction (FACO2), initial inspired gas (VI) conditions, and breath-hold time (t). The quantitative impact upon TLCOsb of the presence or absence of corrections was calculated using TLCOsb measurements from 245 normal subjects. The average change (%) in computed TLCOsb induced by correcting for the above variables is: Hb (+8%); VD (-8%); VDbag (-0.3 to -6%); COHb (+X% for X% COHb); FACO2 (+5%); VI (+4%); t (+7%). Since corrections are made by some laboratories and not by others and since no uniformity exists concerning the corrections to be made, it is possible for two laboratories to choose their computation routines in such a way that they would compute, from the same test results, TLCOsb values which differ by 41%. Standardization of the TLCOsb computation technique is needed.
目前，肺一氧化碳弥散量（TLCOsb）作为一项肺功能检测被广泛应用。尽管大多数研究人员对该检测操作本身已有详尽描述且采用一致的方法，但计算技术却差异很大。通过校正以下因素可引起TLCOsb的显著变化：血液血红蛋白浓度[Hb]、仪器及解剖死腔（VD）、肺泡气样本死腔（VDbag）、碳氧血红蛋白浓度（COHb）、肺泡二氧化碳分数（FACO2）、初始吸入气体（VI）条件以及屏气时间（t）。利用245名正常受试者的TLCOsb测量值，计算了校正与否对TLCOsb的定量影响。校正上述变量后计算所得TLCOsb的平均变化率（%）为：Hb（+8%）；VD（-8%）；VDbag（-0.3%至-6%）；COHb（COHb每增加X%，增加X%）；FACO2（+5%）；VI（+4%）；t（+7%）。由于一些实验室进行校正而另一些实验室不进行校正，且在应做何种校正方面不存在统一标准，所以两个实验室有可能以这样一种方式选择其计算程序，即根据相同的检测结果计算出相差41%的TLCOsb值。因此，需要对TLCOsb计算技术进行标准化。
