碳氧血红蛋白对单次呼吸弥散量的影响：经验校正因子的推导

Effect of carboxyhemoglobin on the single breath diffusing capacity: derivation of an empirical correction factor.

作者信息

Mohsenifar Z, Tashkin D P

出版信息

Respiration. 1979;37(4):185-91. doi: 10.1159/000194025.

DOI:10.1159/000194025

Abstract

The effect on measured DLco of different blood concentrations of COHb produced by breathing CO was studied in 19 healthy nonsmoking subjects. The DLco calculated without adjustment for blood COHb was found to be spuriously reduced by approximately 1% of the observed baseline value for each percent increase in blood COHb saturation. When measuring DLco of subjects who are likely to have elevated COHb blood levels, it is recommended that either blood COHb concentration or equilibrated alveolar PCO be determined in order to correct the DLco for the effect of COHb.

摘要

在19名健康非吸烟受试者中研究了吸入一氧化碳产生的不同血液浓度碳氧血红蛋白对测定的一氧化碳弥散量（DLco）的影响。发现未针对血液碳氧血红蛋白进行校正计算的DLco，会因血液碳氧血红蛋白饱和度每增加1%而比观察到的基线值假性降低约1%。在测量可能具有升高的血液碳氧血红蛋白水平的受试者的DLco时，建议测定血液碳氧血红蛋白浓度或平衡肺泡二氧化碳分压，以便针对碳氧血红蛋白的影响校正DLco。