Ishioka T, Kuwabara N, Fukuda Y
Cancer Lett. 1985 Apr;26(3):277-82. doi: 10.1016/0304-3835(85)90051-5.
The carcinogenicity of orally administered amylopectin sulfate was studied in F344 rats. Amylopectin sulfate induced adenomas and adenocarcinomas in the rat colorectum. The incidences of tumor induction in groups that were given a 5% diet of amylopectin sulfate for 3, 6 and 9 months were 2 out of 20 rats (10%), 9 out of 20 rats (45%) and 12 out of 20 rats (60%), respectively. Squamous metaplasia of the colorectum persisted in all rats and progressed irreversibly. Amylopectin sulfate was deposited in the colorectal lamina propria, submucosa and regional lymph nodes. Amylopectin sulfate induced a lesion similar to that produced by degraded carrageenan in the rat colorectum.
在F344大鼠中研究了口服硫酸支链淀粉的致癌性。硫酸支链淀粉可诱发大鼠结肠直肠癌的腺瘤和腺癌。给予含5%硫酸支链淀粉饮食3个月、6个月和9个月的组中，肿瘤诱发率分别为20只大鼠中的2只（10%）、20只大鼠中的9只（45%）和20只大鼠中的12只（60%）。所有大鼠的结肠直肠均持续存在鳞状化生且不可逆转地进展。硫酸支链淀粉沉积于结肠直肠固有层、黏膜下层和局部淋巴结。硫酸支链淀粉在大鼠结肠直肠中诱发的病变类似于降解角叉菜胶所产生的病变。
