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智能手机辅助脉冲射频能量疗法促进皮肤伤口愈合。

Smartphone administered pulsed radio frequency energy therapy for expedited cutaneous wound healing.

作者信息

Yu Mengxia, Yang Hongjia, Ye Haoteng, Lin Shuhuang, Lu Yujie, Deng Haoqiang, Xu Lulu, Guo Yongxin, Ho John S, Ye Terry Tao

机构信息

Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.

Department of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen, China.

出版信息

NPJ Digit Med. 2025 Feb 15;8(1):103. doi: 10.1038/s41746-025-01462-z.


DOI:10.1038/s41746-025-01462-z
PMID:39955463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11830092/
Abstract

Pulsed radio frequency energy (PRFE) therapy is a non-invasive, electromagnetic field-based treatment modality successfully used in clinical applications. However, conventional PRFE devices are often bulky, expensive, and require extended treatment durations, limiting patient adherence and efficacy. Here, we present a lightweight, cost-effective wearable PRFE system consisting of a flexible electronic bandage and a smartphone. The bandage, mainly composed of an NFC Frequency Doubler (NFD) and a Radiofrequency Energy Radiator (RER), is powered and administered by the smartphone to generate 27.12 MHz radio wave pulses, for simplified, smartphone-enabled PRFE therapy. Its ultra-flexible, battery-free design supports personalized wound care at a low-cost (<US$1). Both electromagnetic field simulation and measurement demonstrated that the proposed PRFE bandage achieves the field strength of clinical-grade PRFE equipment. In rat full-thickness wound models, PRFE therapy improved wound closure rates by ~20%, with enhanced re-epithelialization and angiogenesis compared to controls.

摘要

脉冲射频能量(PRFE)疗法是一种基于电磁场的非侵入性治疗方式,已成功应用于临床。然而,传统的PRFE设备通常体积庞大、价格昂贵,且需要较长的治疗时间,这限制了患者的依从性和疗效。在此,我们展示了一种由柔性电子绷带和智能手机组成的轻便、经济高效的可穿戴PRFE系统。该绷带主要由一个NFC倍频器(NFD)和一个射频能量辐射器(RER)组成,由智能手机供电并进行管理,以产生27.12 MHz的无线电波脉冲,用于简化的、支持智能手机的PRFE治疗。其超柔性、无电池设计支持低成本(<1美元)的个性化伤口护理。电磁场模拟和测量均表明,所提出的PRFE绷带达到了临床级PRFE设备的场强。在大鼠全层伤口模型中,与对照组相比,PRFE疗法使伤口闭合率提高了约20%,同时促进了再上皮化和血管生成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/8f91413e06b1/41746_2025_1462_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/bc385de4ed05/41746_2025_1462_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/f76f91ee3078/41746_2025_1462_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/aeff62b2a22c/41746_2025_1462_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/53bc4cb51b5b/41746_2025_1462_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/8f91413e06b1/41746_2025_1462_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/bc385de4ed05/41746_2025_1462_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/f76f91ee3078/41746_2025_1462_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/aeff62b2a22c/41746_2025_1462_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/53bc4cb51b5b/41746_2025_1462_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718e/11830092/8f91413e06b1/41746_2025_1462_Fig5_HTML.jpg

相似文献

[1]
Smartphone administered pulsed radio frequency energy therapy for expedited cutaneous wound healing.

NPJ Digit Med. 2025-2-15

[2]
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[3]
Non-pharmacological interventions of intermittent fasting and pulsed radiofrequency energy (PRFE) combination therapy promote diabetic wound healing.

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[4]
Pulsed radio frequency energy (PRFE) use in human medical applications.

Electromagn Biol Med. 2011-3

[5]
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Aesthetic Plast Surg. 2011-10-25

[6]
The use of pulsed radio frequency energy therapy in treating lower extremity wounds: results of a retrospective study of a wound registry.

Ostomy Wound Manage. 2011-3

[7]
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Ann Surg. 2012-3

[8]
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Pain Med. 2013-4-8

[9]
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J Foot Ankle Surg. 2012

[10]
Retrospective analysis of pulsed radiofrequency energy therapy use in the treatment of chronic pressure ulcers.

Adv Skin Wound Care. 2012-6

本文引用的文献

[1]
Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure.

Sci Adv. 2024-8-9

[2]
Triboelectric-Responsive Drug Delivery Hydrogel for Accelerating Infected Wound Healing.

Adv Healthc Mater. 2024-6

[3]
A system for bioelectronic delivery of treatment directed toward wound healing.

Sci Rep. 2023-9-7

[4]
Combined Pulsed Magnetic Field and Radiofrequency Electromagnetic Field Enhances MMP-9, Collagen-4, VEGF Synthesis to Improve Wound Healing Via Hif-1α/eNOS Pathway.

Aesthetic Plast Surg. 2023-12

[5]
Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites.

Sci Adv. 2023-2-22

[6]
Wearable, noninvasive, pulsed shortwave (radiofrequency) therapy for analgesia and opioid sparing following outpatient surgery: A proof-of-concept case series.

Pain Pract. 2023-6

[7]
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing.

Nat Biotechnol. 2023-5

[8]
Treating Intractable Postamputation Pain with Noninvasive, Wearable, Nonthermal, Pulsed Shortwave (Radiofrequency) Therapy: A 12-Patient Case Series.

Am J Case Rep. 2022-8-17

[9]
Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora's Box.

Int J Mol Sci. 2022-5-31

[10]
A programmable and skin temperature-activated electromechanical synergistic dressing for effective wound healing.

Sci Adv. 2022-1-28

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