Chen Ziying, Yue Hongyu, Gu Yuanjia, Xie Chaoqun, Ma Jianwen, Xie Fangfang, Wang Guangdong, Yao Fei
Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Respir Med. 2025 Apr;239:107997. doi: 10.1016/j.rmed.2025.107997. Epub 2025 Feb 14.
Traditional Chinese exercise (TCE) has been shown effective for chronic obstructive pulmonary disease (COPD). However, there are no studies investigating the effect of traditional Chinese exercise (TCE) programme on COPD. The aim of this study was to evaluate the effectiveness of specific TCE programme on the pulmonary function in patients with COPD.
76 patients with COPD was randomly assigned to receive either TCE group or control group in a 1:1 ratio. The primary outcome was changes in forced vital capacity (FVC) from baseline to 12 weeks. Secondary outcomes included forced expiratory volume in the first second (FEV1), tidal volume (VT), inspiratory capacity (IC), expiratory reserve volume (ERV), FEV1/FVC, peak expiratory flow (PEF), the 6-min walking test (6MWT), the COPD Assessment Test (CAT), the Short Form 36-item Health Survey (SF-36), modified medical research council scale (mMRC).
After 12 weeks, the TCE group demonstrated a significantly greater improvement of FVC (-12.67; 95 % CI, -18.21 to -7.15; P < 0.001) and FEV1 (-9.70; 95 % CI, -13.73 to -5.68; P < 0.001). But there was no statistically significant difference between groups in FEV1/FVC, PEF, VT, IC or ERV. Besides, patients in the TCE group also reported a statistically significant within-group difference at week 12 in CAT, mMRC and 6MWT. As for eight dimensions of SF-36, patients in TCE group had higher scores in SF-36 (P < 0.05 for 8 dimensions).
Our results demonstrate that the traditional Chinese exercise can serve as an effective therapeutic tool for middle-aged and older patients with COPD.
Chinese Clinical Trial Registry, ChiCTR2300069283, https://www.chictr.org.cn/showproj.html?proj=192116.
已有研究表明传统中式运动（TCE）对慢性阻塞性肺疾病（COPD）有效。然而，尚无研究调查传统中式运动（TCE）方案对COPD的影响。本研究的目的是评估特定的传统中式运动（TCE）方案对COPD患者肺功能的有效性。
76例COPD患者按1:1比例随机分为TCE组或对照组。主要结局是从基线到12周用力肺活量（FVC）的变化。次要结局包括第1秒用力呼气量（FEV1）、潮气量（VT）、吸气量（IC）、呼气储备量（ERV）、FEV1/FVC、呼气峰值流速（PEF）、6分钟步行试验（6MWT）、慢性阻塞性肺疾病评估测试（CAT）、36项简短健康调查（SF-36）、改良医学研究委员会量表（mMRC）。
12周后，TCE组的FVC（-12.67；95%CI，-18.21至-7.15；P<0.001）和FEV1（-9.70；95%CI，-13.73至-5.68；P<0.001）改善更为显著。但两组在FEV1/FVC、PEF、VT、IC或ERV方面无统计学显著差异。此外，TCE组患者在第12周时CAT、mMRC和6MWT的组内差异也有统计学意义。至于SF-36的八个维度，TCE组患者在SF-36中的得分更高（8个维度P<0.05）。
我们的结果表明，传统中式运动可作为中老年COPD患者的有效治疗手段。
中国临床试验注册中心，ChiCTR2300069283，https://www.chictr.org.cn/showproj.html?proj=192116 。
