Lv Jingxia, Li Xiaona, Li Xiaojie, Wang Min, Zhang Zhidong, Wang Dong, Fan Liqiao, Li Yong, Xu Xixia
Department of Surgery, The Fourth Hospital of Hebei Medical University Shijiazhuang 050011, Hebei, China.
Am J Transl Res. 2025 Jan 15;17(1):320-329. doi: 10.62347/HTYY3971. eCollection 2025.
To investigate the factors influencing inadequate enteral nutrition (EN) after radical gastrectomy for gastric cancer and its impact on clinical outcomes.
A retrospective analysis was conducted on 212 gastric cancer patients who underwent radical surgery and received EN at the Fourth Hospital of Hebei Medical University. Patients were divided into two groups based on whether they achieved 60% of their caloric needs by the sixth postoperative day. Univariate and multivariate logistic regression models were used to identify factors associated with inadequate EN.
Inadequate EN was observed in 26.89% of the patients. Key factors associated with insufficient EN included delayed initiation of nutrition, increased intra-abdominal and central venous pressures, use of sedatives, and delayed early mobility (all P<0.05). Patients with inadequate EN had longer hospital stays, delayed bowel recovery, higher postoperative complication rates, and lower overall and disease-free survival rates (all P<0.05).
Inadequate enteral nutrition is an independent risk factor for poor clinical outcomes in gastric cancer patients after radical gastrectomy. Early and adequate nutritional support is essential to improve recovery and long-term survival.
探讨影响胃癌根治术后肠内营养（EN）不足的因素及其对临床结局的影响。
对河北医科大学第四医院212例行根治性手术并接受EN的胃癌患者进行回顾性分析。根据术后第6天是否达到热量需求的60%将患者分为两组。采用单因素和多因素logistic回归模型确定与EN不足相关的因素。
26.89%的患者存在EN不足。与EN不足相关的关键因素包括营养启动延迟、腹内压和中心静脉压升高、使用镇静剂以及早期活动延迟（均P<0.05）。EN不足的患者住院时间更长、肠道恢复延迟、术后并发症发生率更高，总体生存率和无病生存率更低（均P<0.05）。
肠内营养不足是胃癌患者根治术后临床结局不良的独立危险因素。早期和充足的营养支持对于改善康复和长期生存至关重要。
