Jo Yongdeok, Kushram Priya, Bose Susmita
W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, USA.
Biomater Sci. 2025 Mar 11;13(6):1568-1577. doi: 10.1039/d4bm01188k.
Improving early osseointegration and removing residual cancer cells after tumor removal requires the development of novel bone implants with osteogenic and anti-cancer properties. Here, curcumin and vitamin D3 (Cur/VitD3) are loaded into calcium phosphate (CaP) matrices to improve osteogenesis and inhibit the proliferation of human osteosarcoma cells. Patient-specific, 3D-printed tricalcium phosphate (TCP) loaded with Cur/VitD3 increases the viability of osteoblast cells after 11 days. When delivered in combination, Cur/VitD3 loaded hydroxyapatite (HA)-coated Ti64 implant promotes new bone formation by 2.7-fold compared to the control after 6 weeks. This delivery system also decreases osteosarcoma cell viability relative to the 3D-printed TCP after day 11, indicating its anti-cancer properties. These findings contribute to the understanding of multifunctional CaP bone grafts to improve early osteogenesis after severe bone trauma and suppress the proliferation of osteosarcoma cells after tumor resection surgery.
改善早期骨整合以及在肿瘤切除后清除残留癌细胞需要开发具有成骨和抗癌特性的新型骨植入物。在此，将姜黄素和维生素D3（Cur/VitD3）负载到磷酸钙（CaP）基质中，以改善成骨作用并抑制人骨肉瘤细胞的增殖。负载Cur/VitD3的患者特异性3D打印磷酸三钙（TCP）在11天后可提高成骨细胞的活力。当联合递送时，负载Cur/VitD3的羟基磷灰石（HA）涂层Ti64植入物在6周后促进新骨形成的能力比对照提高了2.7倍。该递送系统在第11天后相对于3D打印的TCP也降低了骨肉瘤细胞的活力，表明其具有抗癌特性。这些发现有助于理解多功能CaP骨移植，以改善严重骨创伤后的早期成骨作用，并抑制肿瘤切除手术后骨肉瘤细胞的增殖。
