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酒精中毒结局研究评估介绍。

An introduction to the evaluation of alcoholism outcome studies.

作者信息

Gottheil E

出版信息

Curr Alcohol. 1979;7:275-85.

PMID:399602
Abstract

The results of outcome studies in the field of alcoholism have been challenged as not providing clear and definitive demonstrations of the effectiveness of alcoholism treatment. This has not been due to studies showing negative results, or to a lack of studies reporting positive results. The difficulty has been that the studies failed to satisfy the standards of experimentally minded methodologists. Many methodological problems with respect to patient, treatment, and criterion variables were described which will require a great deal of basic research for their solution. Others may not be soluble. Drawing a representative sample of alcoholics may not be feasible. Assigning patients at random to treatments and no treatment who are uninterested, who desire particular treatments, or who are in need of specific treatments is impractical and socially unacceptable. Matching or randomly assigning therapists to provide consistent, measured, and equal amounts of specific therapies is similarly unrealistic. Determining what constitutes a good therapeutic outcome may be more of a philosophic than a scientific issue. Applying experimental standards to human outcome studies is inappropriate. The state of the art with respect to evaluating the effectiveness of alcoholism treatment is not ready for experimental investigations or cost-benefits analyses. Despite all these problems, a review of 384 studies indicates that two-thirds of the patients improve following alcoholism treatment. Research studies are increasingly sophisticated. A great deal has been and is continuing to be learned about patient characteristics, treatment methods, and matching patients to treatments.

摘要

酗酒领域的疗效研究结果受到了质疑,因为这些研究并未清晰明确地证明酗酒治疗的有效性。这并非是由于研究显示出负面结果,也不是因为缺乏报告正面结果的研究。困难在于这些研究未能满足具有实验思维的方法学家的标准。文中描述了许多与患者、治疗和标准变量相关的方法学问题,解决这些问题需要大量的基础研究。其他一些问题可能无法解决。抽取具有代表性的酗酒者样本可能不可行。将对治疗不感兴趣、渴望特定治疗或需要特定治疗的患者随机分配到接受治疗组和不接受治疗组是不切实际且在社会上不可接受的。同样,匹配或随机分配治疗师以提供一致、适度且等量的特定疗法也不现实。确定什么构成良好的治疗效果可能更多是一个哲学问题而非科学问题。将实验标准应用于人类疗效研究是不合适的。就评估酗酒治疗效果而言,目前的技术水平还不适用于进行实验研究或成本效益分析。尽管存在所有这些问题,但对384项研究的综述表明,三分之二的患者在接受酗酒治疗后病情有所改善。研究越来越复杂。人们已经并且正在不断深入了解患者特征、治疗方法以及患者与治疗的匹配情况。

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