Karhunen M, Koskela O, Teisala K, Suikkari A M, Mattila J
Chemotherapy. 1985;31(3):228-36. doi: 10.1159/000238341.
The purpose of this prospective, double-blind, placebo-controlled study was to clarify the effect of a single intravenous infusion of 500 mg of tinidazole on infections that followed a caesarean section. 80 consecutive caesarean-section patients and thereafter 72 women undergoing non-elective caesarean section were randomly assigned to two groups, each receiving intravenous infusions at cord clamping. In the entire sample the incidence of endometritis/wound infection in the placebo group was 27.3% (21/77) versus 10.7% (8/75) in the tinidazole group (p less than 0.01). In the non-elective caesarean-section group the incidence of endometritis/wound infection was 39.6% (21/53) in the placebo group versus 14.3% (7/49) in the tinidazole group (p less than 0.01). 27 positive bacterial cultures yielded a pure anaerobic growth in 59% (16/27) of cases, of which 87.5% (14/16) were treated successfully with oral tinidazole.
这项前瞻性、双盲、安慰剂对照研究的目的是阐明单次静脉输注500毫克替硝唑对剖宫产术后感染的影响。连续80例剖宫产患者，随后72例非选择性剖宫产妇女被随机分为两组，每组在脐带夹闭时接受静脉输注。在整个样本中，安慰剂组子宫内膜炎/伤口感染的发生率为27.3%（21/77），而替硝唑组为10.7%（8/75）（p<0.01）。在非选择性剖宫产组中，安慰剂组子宫内膜炎/伤口感染的发生率为39.6%（21/53），而替硝唑组为14.3%（7/49）（p<0.01）。27份阳性细菌培养物中有59%（16/27）的病例呈现纯厌氧菌生长，其中87.5%（14/16）的病例经口服替硝唑治疗成功。
