Appelbaum P C, Moodley J, Chatterton S A, Cowan D B, Africa C W
Chemotherapy. 1980;26(2):145-51. doi: 10.1159/000237897.
The influence of prophylactic tinidazole therapy on vaginal carriage rates of anaerobes and the development of post-operative anaerobic infection was studied in 100 women undergoing abdominal hysterectomy. Tinidazole prophylaxis (50 patients) led to a decrease of anaerobe vaginal carriage rate from 56% pre-operatively to 10 and 30% on the third and seventh post-operative days, respectively. In the control group (50 patients), no significant decrease in anaerobe yield was noted, corresponding percentages being 72, 64 and 74. Post-operative infection occurred in 34 cases (28 controls, 6 tinidazole prophylaxis). Wound swabs from patients in the latter group did not yield anaerobes on culture, and infections either resolved spontaneously (2 cases) or responded to tinidazole therapy, with or without addition of ampicillin and kanamycin (4 cases). In the control group, 21 cases of post-operative wound infection and 4 of vault infection were seen. Wound swabs from 6 of the former group yielded aerobes only and 10 mixed growth of aerobes/anaerobes. Post-operative wound/vault infections in control patients cleared spontaneously (18 cases) or responded to imidazole therapy, with or without ampicillin and kanamycin (7 cases). These data suggest that tinidazole may be a useful adjunct in imidazole prophylaxis and treatment of anaerobic infection.
对100例行腹部子宫切除术的女性进行研究，以探讨预防性应用替硝唑治疗对厌氧菌阴道携带率及术后厌氧感染发生情况的影响。替硝唑预防组（50例患者）使厌氧菌阴道携带率从术前的56%分别降至术后第3天和第7天的10%和30%。在对照组（50例患者）中，未观察到厌氧菌产生有显著下降，相应百分比分别为72%、64%和74%。术后感染发生34例（28例对照，6例替硝唑预防组）。替硝唑预防组患者的伤口拭子培养未发现厌氧菌，感染要么自行缓解（2例），要么对替硝唑治疗有反应，无论是否加用氨苄西林和卡那霉素（4例）。在对照组中，观察到21例术后伤口感染和4例穹窿感染。前一组6例患者的伤口拭子仅培养出需氧菌，10例培养出需氧菌/厌氧菌混合菌。对照组患者的术后伤口/穹窿感染自行缓解（18例）或对咪唑类治疗有反应，无论是否加用氨苄西林和卡那霉素（7例）。这些数据表明，替硝唑可能是咪唑类预防和治疗厌氧感染的有用辅助药物。
