Risk factor analysis of adjacent vertebral compression fracture following the surgery of percutaneous kyphoplasty in postmenopausal women.

To evaluate the risk factors for adjacent vertebral compression fracture(AVCF) following the surgery of percutaneous kyphoplasty (PKP) in postmenopausal women. Two hundred and ninety-seven postmenopausal female patients had been reviewed, underwent PKP surgery between January 2016 and December 2020, were divided into two groups according to whether or not AVCF. Receiver operating characteristic (ROC) curves were generated to analyze the sensitivity and specificity of the relative risk factors in the identification of AVCF. In this study of 297 postmenopausal women who underwent PKP, 67 developed AVCF during follow-up. There were no significant differences in BMI, surgical method, or cement leakage between the groups. The AVCF group was older, had lower BMD, less bone cement volume per section, higher VHA, and larger VKAC. The non-fracture group had lower postoperative VAS and fewer surgical vertebrae. The model showed good discrimination with age, BMD, postoperative VAS, VHR, and VKAC. ROC analysis indicated that a postoperative with high VHR, high VKAC or VAS score > 2.5 was highly predictive of AVCF in postmenopausal women after PKP. In the context of PKP for OVCF in postmenopausal women, it is crucial to avoid excessive VHR and VKAC. Postoperatively, clinicians should prioritize pain management strategies to ensure optimal patient outcomes.