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用于癌症检测、手术和原位生物打印的无动力软体机器人。

Motor-Free Soft Robots for Cancer Detection, Surgery, and In Situ Bioprinting.

作者信息

Nguyen Chi Cong, Davies James, Ashok Aditya, Hoang Trung Thien, Ehteda Anahid, Dang Tran Bach, Nicotra Emanuele, Tran Hien A, Sharma Bibhu, Zhu Kefan, Phan Phuoc Thien, Ji Adrienne, Wan Jingjing, Rnjak-Kovacina Jelena, Vittorio Orazio, Phan Hoang-Phuong, Lovell Nigel Hamilton, Do Thanh Nho

机构信息

Graduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE), UNSW Sydney, Kensington Campus, Sydney, NSW, 2052, Australia.

School of Mechanical and Manufacturing Engineering, Faculty of Engineering, UNSW Sydney, Kensington Campus, Sydney, NSW, 2052, Australia.

出版信息

Adv Healthc Mater. 2025 May;14(14):e2404623. doi: 10.1002/adhm.202404623. Epub 2025 Feb 17.

Abstract

Recent advancements in teleoperated surgical robotic systems (TSRSs) for minimally invasive surgery (MIS) have significantly improved diagnostic and surgical outcomes. However, as the complexity of MIS procedures continues to grow, there is an increasing need to enhance surgical tools by integrating advanced functionalities into these instruments for superior medical results. Despite recent advancements, TSRSs face significant challenges, including rigidity, suboptimal actuation methods, large sizes, and complex control mechanisms. This paper presents a portable, motor-free soft robotic system equipped with soft robotic arms (SRAs) that provides an innovative solution for performing MIS within complex human organs. Unlike conventional approaches, these SRAs leverage a soft fibrous syringe architecture for operation, eliminating the need for complex control systems. This design achieves precise motion control with mean errors <300 µm, effectively minimizing physical tremors. Two SRAs-one with and one without a central lumen-are developed. By integrating microelectrodes into the SRAs, the system demonstrates capabilities to support cancer detection via electrical impedance measurements and to perform radio-frequency ablation for surgical treatments. Additionally, the system supports biomaterial injections and in situ 3D printing for internal wound healing. This simple, cost-effective platform represents a promising new direction for developing TSRSs in MIS.

摘要

用于微创手术(MIS)的远程操作手术机器人系统(TSRS)的最新进展显著改善了诊断和手术效果。然而,随着MIS手术复杂性的不断增加,越来越需要通过将先进功能集成到这些器械中来增强手术工具,以获得更好的医疗效果。尽管有最近的进展,但TSRS仍面临重大挑战,包括刚性、次优驱动方法、尺寸大以及控制机制复杂。本文介绍了一种配备软机器人臂(SRA)的便携式、无电机软机器人系统,该系统为在复杂人体器官内进行MIS提供了一种创新解决方案。与传统方法不同,这些SRA利用软纤维注射器结构进行操作,无需复杂的控制系统。这种设计实现了平均误差<300 µm的精确运动控制,有效减少了身体震颤。开发了两种SRA——一种有中心腔,一种没有中心腔。通过将微电极集成到SRA中,该系统展示了通过电阻抗测量支持癌症检测以及进行射频消融手术治疗的能力。此外,该系统支持生物材料注射和原位3D打印以促进内部伤口愈合。这个简单、经济高效的平台代表了在MIS中开发TSRS的一个有前景的新方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62c/12118338/a35c17f412be/ADHM-14-0-g001.jpg

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