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[肺结外边缘区淋巴瘤的研究进展]

[Research Progress of Pulmonary Extranodal Marginal Zone Lymphoma].

作者信息

Zhang Shaowei

机构信息

Department of Cardiothoracic Surgery, Pingdingshan Medical District, 989th Hospital of Joint Logistics Support Force, 
Pingdingshan 467021, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2024 Dec 20;27(12):947-955. doi: 10.3779/j.issn.1009-3419.2024.106.31.

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common primary pulmonary lymphoma, which is an indolent B-cell lymphoma thought to originate from marginal zone B cells. Its pathophysiology is closely related to chronic antigenic stimulation, regardless of whether the antigens are auto-antigens or of microbial origin. Due to its nonspecific clinical presentation and low prevalence, pulmonary MALT lymphoma is often misdiagnosed. The disease is slow-growing, and different treatments have shown good efficacy, but its optimal treatment is somewhat controversial. This paper reviews the epidemiology, pathogenesis, clinical manifestations, computed tomography (CT) features, pathological diagnosis, treatment and prognosis of pulmonary MALT lymphoma, providing reference for clinicians to further understanding of the disease.
.

摘要

黏膜相关淋巴组织(MALT)淋巴瘤是最常见的原发性肺淋巴瘤,是一种惰性B细胞淋巴瘤,被认为起源于边缘区B细胞。其病理生理学与慢性抗原刺激密切相关,无论抗原是自身抗原还是微生物来源。由于其临床表现不具特异性且发病率低,肺MALT淋巴瘤常被误诊。该疾病生长缓慢,不同的治疗方法已显示出良好疗效,但其最佳治疗方案仍存在一定争议。本文综述了肺MALT淋巴瘤的流行病学、发病机制、临床表现、计算机断层扫描(CT)特征、病理诊断、治疗及预后,为临床医生进一步了解该疾病提供参考。

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本文引用的文献

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Leuk Lymphoma. 2024 Jun;65(6):746-757. doi: 10.1080/10428194.2024.2329328. Epub 2024 Mar 20.
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Leuk Lymphoma. 2023 Dec;64(13):2195-2201. doi: 10.1080/10428194.2023.2255706. Epub 2023 Sep 14.
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Clinical relevance of molecular aspects in extranodal marginal zone lymphoma: a critical appraisal.
Ther Adv Med Oncol. 2023 Jun 22;15:17588359231183565. doi: 10.1177/17588359231183565. eCollection 2023.

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