Iacopetta Bianca M, Lam David C L, Ngai Jenny C L, Chan Johnny W M, Chiang Fifian K Y, Lui Macy M S, Law W L, Chan Ken K P, McVeigh Joanne, Peddle-McIntyre Carolyn J, Lee Y C Gary
Pleural Medicine Unit, Institute for Respiratory Health, Perth, Australia.
Exercise Medicine Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
ERJ Open Res. 2025 Feb 17;11(1). doi: 10.1183/23120541.00399-2024. eCollection 2025 Jan.
Accelerometery is used to measure activity behaviours in patients with malignant pleural effusion (MPE). This study aimed to evaluate physical activity and sedentary behaviour profiles of patients with MPE in Hong Kong, and to explore relationships between activity behaviours and quality of life (QoL). We also compared clinician-recorded performance status measures with objective measures of activity levels.
Participants wore an Actigraph GT3X+ accelerometer continuously for 7 consecutive days. The EuroQoL 5 Dimensions 5 Levels (EQ-5D-5L) was used to assess five dimensions of QoL and correlate with activity behaviours. The Eastern Cooperative Oncology Group (ECOG) performance status was documented by clinicians at baseline.
Fifty-one patients with MPE received accelerometers; 94% had ≥1 valid day of data. Participants spent 76% (sd 2.32) of waking hours sedentary, 23% (sd 1.40) of waking hours in light activity and 0.3% (median, interquartile range 0.0-1.5) in moderate-to-vigorous physical activity (MVPA). Higher light activity and MVPA behaviours were associated with increased participation in self-care tasks (r=-0.43, p=0.003; r=-0.45, p=0.001, respectively) and usual activities (r=-0.42, p=0.003; r=-0.45, p=0.001, respectively). Patients with an ECOG status of 0 or 1 spent an average of 75% of waking hours sedentary.
This is the first report of physical activity behaviours in patients with MPE in Hong Kong, demonstrating high sedentary behaviours and low physical activity which correlated to dimensions of QoL. Clinician-rated performance status was not reflected in accelerometery data, suggesting a discrepancy between performance status measures and objective measures of activity in patients with MPE.
加速度计用于测量恶性胸腔积液（MPE）患者的活动行为。本研究旨在评估香港MPE患者的身体活动和久坐行为特征，并探讨活动行为与生活质量（QoL）之间的关系。我们还比较了临床医生记录的体能状态指标与活动水平的客观测量结果。
参与者连续7天佩戴Actigraph GT3X+加速度计。采用欧洲五维度健康量表（EQ-5D-5L）评估生活质量的五个维度，并与活动行为进行关联。临床医生在基线时记录东部肿瘤协作组（ECOG）体能状态。
51例MPE患者佩戴了加速度计；94%的患者有≥1个有效数据日。参与者清醒时间的76%（标准差2.32）处于久坐状态，23%（标准差1.40）处于轻度活动状态，0.3%（中位数，四分位间距0.0-1.5）处于中度至剧烈身体活动（MVPA）状态。较高的轻度活动和MVPA行为与自理任务参与度增加相关（分别为r=-0.43，p=0.003；r=-0.45，p=0.001），与日常活动参与度增加相关（分别为r=-0.42，p=0.003；r=-0.45，p=0.001）。ECOG体能状态为0或1的患者平均清醒时间的75%处于久坐状态。
这是香港MPE患者身体活动行为的首份报告，表明久坐行为多而身体活动少，且与生活质量维度相关。加速度计数据未反映临床医生评定的体能状态，提示MPE患者体能状态指标与活动客观测量结果之间存在差异。
