Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, 6027, Australia.
Respiratory Department, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Support Care Cancer. 2017 Oct;25(10):3133-3141. doi: 10.1007/s00520-017-3721-9. Epub 2017 Apr 28.
Malignant pleural effusion (MPE) affects 1 million people worldwide annually and can significantly impair physical activity. Accelerometry is a validated method of objectively assessing physical activity. The purpose of this study was to determine the compliance in patients with MPE to accelerometry and describe their activity.
Patients with MPE wore an Actigraph GT3X accelerometer over a 7-day continuous wear protocol. Compliance was measured as the percent of patients who had ≥4 valid days (i.e., 8-h/day of waking wear-time). Eastern Cooperative Oncology Group performance status was documented the day of actigraphy initialization.
Forty-six patients with MPE received accelerometers; 44 (95.7%) returned their device. No complications were reported on their use. Forty subjects (90.9%) had ≥4 valid days of wear-time. Patients spent most of their waking hours sedentary [mean 11.0 h (SD 1.95)], with limited participation in moderate and vigorous physical activity [mean 9.5 min (SD 14.16)]. Compared to patients with better performance status (n = 32), patients with poorer performance status (n = 11) spent significantly more hours/day sedentary [mean difference 2.1 (CI 0.86-3.32); p = 0.001], as did those who survived <3 months (n = 5) compared to >12 months (n = 27) [mean difference 2.6 (CI 0.49-4.77); p = 0.013).
Accelerometry was applied successfully in patients with MPE with high compliance and no adverse events. This is the first reported objectively measured physical activity in patients with MPE and revealed high sedentary behavior and low physical activity. The data reflected patient performance status and discriminated between survival groups. Accelerometry can provide a useful measure for future interventional studies in patients with MPE.
恶性胸腔积液（MPE）每年影响全球 100 万人，并可显著降低体力活动水平。加速度计是一种客观评估体力活动的验证方法。本研究的目的是确定 MPE 患者对加速度计的依从性，并描述他们的活动情况。
MPE 患者佩戴 Actigraph GT3X 加速度计，进行为期 7 天的连续佩戴方案。依从性以有≥4 天有效佩戴（即 8 小时/天的清醒佩戴时间）的患者比例来衡量。在进行加速度计初始化的当天，记录患者的东部肿瘤协作组表现状态。
46 名 MPE 患者接受了加速度计；44 名（95.7%）患者归还了设备。使用过程中未报告任何并发症。40 名患者（90.9%）有≥4 天有效佩戴时间。患者在清醒时间大部分时间都处于久坐状态[平均 11.0 小时（SD 1.95）]，很少参加中等强度和剧烈体力活动[平均 9.5 分钟（SD 14.16）]。与表现状态较好的患者（n=32）相比，表现状态较差的患者（n=11）每天久坐的时间明显更长[平均差异 2.1（CI 0.86-3.32）；p=0.001]，而存活时间<3 个月的患者（n=5）与存活时间>12 个月的患者（n=27）相比，每天久坐的时间也明显更长[平均差异 2.6（CI 0.49-4.77）；p=0.013]。
加速度计在 MPE 患者中应用成功，具有较高的依从性且无不良事件。这是首次报道 MPE 患者的客观体力活动测量数据，结果显示患者存在高静坐行为和低体力活动。这些数据反映了患者的表现状态，并区分了生存组。加速度计可为未来 MPE 患者的干预性研究提供有用的衡量指标。
