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来自昆虫病原真菌TBRC-BCC 76666培养物的生物活性聚酮化合物。

Bioactive polyketides from cultures of the entomopathogenic fungus TBRC-BCC 76666.

作者信息

Kornsakulkarn Jittra, Auncharoen Patchanee, Noisripoom Wasana, Mongkolsamrit Suchada, Thongpanchang Chawanee

机构信息

National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA) 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang Pathum Thani 12120 Thailand

出版信息

RSC Adv. 2025 Feb 17;15(7):5234-5241. doi: 10.1039/d4ra08431d. eCollection 2025 Feb 13.

DOI:10.1039/d4ra08431d
PMID:39963459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11831733/
Abstract

Entomopathogenic fungi of the genus Hypocrella are known to produce bioactive compounds, in particular polyketides. Here, a chemical investigation of the entomopathogenic fungus strain TBRC-BCC 76666 was performed to identify possible novel compounds indicated from HPLC and H NMR spectra profiles of culture extracts. Eight novel compounds were isolated, including six new polyketides (1-6) and two other naturally occurring compounds (7-8), along with seven known compounds. The compound structures were established by spectroscopic analysis, the application of modified Mosher's method, and electronic circular dichroism. Compounds 1 and 5 were cytotoxic against both NCI-H187 and Vero cells (IC = 9.9 and 58.9 μM, respectively), whereas compound 4 was active only against MCF-7 cells (IC = 42.5 μM). Ascherxanthone B (9) exhibited antiproliferative activity against all cell lines tested (, mammalian, and fungal), with IC and MIC values in the range 0.9-30.5 μM.

摘要

已知虫瘟霉属的昆虫病原真菌会产生生物活性化合物，尤其是聚酮化合物。在此，对昆虫病原真菌菌株TBRC - BCC 76666进行了化学研究，以鉴定从培养提取物的高效液相色谱和氢核磁共振光谱图中显示的可能的新化合物。分离出了8种新化合物，包括6种新的聚酮化合物（1 - 6）和另外两种天然存在的化合物（7 - 8），以及7种已知化合物。通过光谱分析、改良莫舍尔法的应用和电子圆二色性确定了化合物的结构。化合物1和5对NCI - H187和Vero细胞均具有细胞毒性（IC分别为9.9和58.9 μM），而化合物4仅对MCF - 7细胞有活性（IC = 42.5 μM）。Ascherxanthone B（9）对所有测试的细胞系（哺乳动物和真菌）均表现出抗增殖活性，IC和MIC值在0.9 - 30.5 μM范围内。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/5d166c167f07/d4ra08431d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/a4de89423f91/d4ra08431d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/55177c408aff/d4ra08431d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/f910c571dbf0/d4ra08431d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/2f3661d4abb6/d4ra08431d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/2d686c07a54f/d4ra08431d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/5d166c167f07/d4ra08431d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/a4de89423f91/d4ra08431d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/55177c408aff/d4ra08431d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/f910c571dbf0/d4ra08431d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/2f3661d4abb6/d4ra08431d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/2d686c07a54f/d4ra08431d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e50/11831733/5d166c167f07/d4ra08431d-f6.jpg

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