Rausch J L, Janowsky D S, Risch S C, Huey L Y
Psychiatry Res. 1986 Oct;19(2):105-12. doi: 10.1016/0165-1781(86)90003-x.
Platelet serotonin uptake was kinetically measured in 32 psychiatric inpatients and 32 age- and sex-matched controls. Patients were categorized into four groups: depressed patients, manic bipolars, other affective disorders, and nonaffective psychiatric disorders. A randomized block factorial analysis of variance indicated that the depressed patients had a significantly lower maximal velocity (Vmax) of serotonin uptake in comparison to matched controls, without a statistically significant difference in Km. No statistically significant difference was found for any of the other diagnostic groups in comparison to controls for Vmax or Km. These results are compared with previous studies of platelet serotonin transport in clinically depressed patients and in physostigmine-induced depression.
对32名精神科住院患者和32名年龄及性别匹配的对照者进行了血小板5-羟色胺摄取的动力学测量。患者被分为四组：抑郁症患者、双相躁狂症患者、其他情感障碍患者和非情感性精神障碍患者。随机区组析因方差分析表明，与匹配的对照组相比，抑郁症患者的5-羟色胺摄取最大速度（Vmax）显著降低，而米氏常数（Km）无统计学显著差异。与对照组相比，其他诊断组在Vmax或Km方面均未发现统计学显著差异。将这些结果与先前关于临床抑郁症患者和毒扁豆碱诱发抑郁症患者血小板5-羟色胺转运的研究进行了比较。
