Esplugues J V, Bulbena O, Escolar G, Martí-Bonmatí E, Esplugues J
Eur J Pharmacol. 1985 Feb 26;109(2):145-51. doi: 10.1016/0014-2999(85)90415-7.
The effects of zinc acexamate on gastric defensive systems were evaluated in the rat. Gastric ulcers induced by oral administration of three necrotic agents (0.6 N HCl, 25% NaCl, 100% ethanol) were markedly reduced by different pretreatments with zinc acexamate. This cytoprotective effect was not modified by previous treatment with indomethacin (30 mg/kg orally). Zinc acexamate pretreatment also prevents the disruption of the gastric mucosal barrier induced by aspirin (40 mM) and increases mucus production in the gastric glands and tracheal walls. These observations suggest that the antiulcer effects described for zinc salts could be the result, at least partly, of an action increasing gastric mucosal defensive systems.
在大鼠中评估了醋氨己酸锌对胃防御系统的影响。通过口服三种坏死剂（0.6N盐酸、25%氯化钠、100%乙醇）诱导的胃溃疡，经醋氨己酸锌不同预处理后显著减轻。吲哚美辛（30mg/kg口服）预处理不会改变这种细胞保护作用。醋氨己酸锌预处理还可防止阿司匹林（40mM）诱导的胃黏膜屏障破坏，并增加胃腺和气管壁中的黏液分泌。这些观察结果表明，锌盐的抗溃疡作用至少部分可能是增加胃黏膜防御系统作用的结果。
