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培养的人内皮细胞释放的糖胺聚糖类肝素样活性的效力。

The potency of heparin-like activity of glycosaminoglycans released by human endothelial cells in culture.

作者信息

Shimada K, Kusumoto I, Ozawa T

出版信息

Experientia. 1985 May 15;41(5):671-3. doi: 10.1007/BF02007713.

DOI:10.1007/BF02007713
PMID:3996545
Abstract

Glycosaminoglycans isolated from culture medium conditioned by human endothelial cells showed heparin-like anti-thrombin III cofactor activity measured by Xa inhibition. Their activity was relatively weak, 0.1% of the potency of heparin, but was approximately 5-fold more potent than that of glycosaminoglycans derived from vascular smooth muscle cells.

摘要

从人内皮细胞条件培养基中分离出的糖胺聚糖，通过Xa抑制法测定显示出类肝素抗凝血酶III辅因子活性。它们的活性相对较弱，仅为肝素效力的0.1%，但比源自血管平滑肌细胞的糖胺聚糖的活性约强5倍。

相似文献

1
The potency of heparin-like activity of glycosaminoglycans released by human endothelial cells in culture.培养的人内皮细胞释放的糖胺聚糖类肝素样活性的效力。
Experientia. 1985 May 15;41(5):671-3. doi: 10.1007/BF02007713.
2
Demonstration of a direct anti-factor Xa activity in certain heparin-related glycosaminoglycans.某些肝素相关糖胺聚糖中直接抗Xa因子活性的证明。
Thromb Res. 1982 Jun 15;26(6):401-9. doi: 10.1016/0049-3848(82)90312-7.
3
Cultured endothelial cells produce a heparinlike inhibitor of smooth muscle cell growth.培养的内皮细胞产生一种平滑肌细胞生长的类肝素抑制剂。
J Cell Biol. 1981 Aug;90(2):372-9. doi: 10.1083/jcb.90.2.372.
4
GAGs-potentiated inhibition of thrombin, factor Xa and plasmin in plasma and in a purified system containing antithrombin III - correlation with total charge density.糖胺聚糖在血浆及含有抗凝血酶III的纯化系统中对凝血酶、因子Xa和纤溶酶的增强抑制作用——与总电荷密度的相关性
Thromb Haemost. 1981 Dec 23;46(4):749-51.
5
Role of heparin and heparinlike molecules in thrombosis and atherosclerosis.肝素及类肝素分子在血栓形成和动脉粥样硬化中的作用。
Fed Proc. 1985 Feb;44(2):404-9.
6
Effects on platelets and on the clotting system of four glycosaminoglycans extracted from hog mucosa and one extracted from aortic intima of the calf.从猪黏膜中提取的四种糖胺聚糖以及从小牛主动脉内膜中提取的一种糖胺聚糖对血小板和凝血系统的影响。
J Med. 1986;17(5-6):331-46.
7
Anti-factor Xa activity of heparan sulphate.硫酸乙酰肝素的抗Xa因子活性。
Thromb Res. 1979 Feb-Mar;14(2-3):501-6. doi: 10.1016/0049-3848(79)90258-5.
8
Anticoagulant activity of galactosaminoglucuronoglycan: a pharmacological study.
Drugs Exp Clin Res. 1991;17(1):65-73.
9
Antithrombin III, the major modulator of intravascular coagulation, is synthesized by human endothelial cells.抗凝血酶III是血管内凝血的主要调节因子，由人内皮细胞合成。
Thromb Haemost. 1981 Aug 28;46(2):504-6.
10
Evidence for a plasma inhibitor of the heparin accelerated inhibition of factor Xa by antithrombin III.抗凝血酶III对因子Xa肝素加速抑制作用存在血浆抑制剂的证据。
Biochim Biophys Acta. 1979 Sep 3;586(3):584-93. doi: 10.1016/0304-4165(79)90049-7.

本文引用的文献

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A modified uronic acid carbazole reaction.一种改良的糖醛酸咔唑反应。
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Anti-clotting activity of endothelial cell cultures and heparan sulfate proteoglycans.内皮细胞培养物和硫酸乙酰肝素蛋白聚糖的抗凝血活性。
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Changes in cell-surface glycosaminoglycans in human diploid fibroblasts during in vitro aging.人二倍体成纤维细胞体外老化过程中细胞表面糖胺聚糖的变化。
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5
Antibodies to the heparan sulfate proteoglycans synthesized by endothelial cell cultures.针对内皮细胞培养物合成的硫酸乙酰肝素蛋白聚糖的抗体。
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Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.源自脐静脉的人内皮细胞培养。通过形态学和免疫学标准进行鉴定。
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8
The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.平滑肌细胞。II. 培养中平滑肌的生长及弹性纤维的形成。
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Assay of heparin in plasma using a chromogenic substrate for activated factor X.使用针对活化因子X的显色底物测定血浆中的肝素。
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Distribution of acidic glycosaminoglycans in the intima, media and adventitia of bovine aorta and their anticoagulant properties.酸性糖胺聚糖在牛主动脉内膜、中膜和外膜中的分布及其抗凝特性。
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