Galenko-Iaroshevskiĭ P A, Shadurskiĭ K S, Tikhonov A V
Farmakol Toksikol. 1984 Jul-Aug;47(4):54-9.
It has been shown in experiments on anesthetized cats and dogs that lithium hydroxybutyrate produces antiarrhythmic action in central aconitic and strophanthine arrhythmias, prevents the development of ventricular fibrillation, and shows antiarrhythmic activity in strong occlusion on the coronary artery. The drug does not remove the atrial and aconitic patterns of arrhythmia. Lithium chloride also exhibits antiarrhythmic action in central aconitic arrhythmia, being inferior to lithium hydroxybutyrate. The drug does not influence central strophanthine arrhythmia and does not show antifibrillation activity.
在对麻醉猫和狗进行的实验中已表明，羟基丁酸锂对中枢乌头碱和毒毛花苷引起的心律失常具有抗心律失常作用，可防止心室颤动的发生，并在冠状动脉强烈阻塞时显示出抗心律失常活性。该药物不能消除心房和乌头碱型心律失常。氯化锂在中枢乌头碱性心律失常中也表现出抗心律失常作用，但不如羟基丁酸锂。该药物对中枢毒毛花苷引起的心律失常没有影响，也没有抗纤颤活性。
