Anjaneyulu Bendi, Chauhan Vishaka, Bhathiwal Anirudh Singh, Mittal Chinmay, Afshari Mozhgan
Department of Chemistry, Presidency University, Rajanukunte, Itgalpura, Bangalore, Karnataka, India.
Department of Chemistry, Faculty of Science, SGT University, Gurugram, Haryana, India.
Chem Biodivers. 2025 Jul;22(7):e202403328. doi: 10.1002/cbdv.202403328. Epub 2025 Mar 4.
Pyridine is one of the significant six-membered N-heterocycles that has gained the attention of the scientific community because it is an integral part of various medicinally important natural products. There is a sizable and expanding market for pyridine derivatives due to their many pharmaceutical, medicinal, and agricultural uses. Numerous chemicals are being tested in clinical studies, in which pyridine analogs have occupied the top position. Pyridine scaffolds are also becoming more and more prominent for the use of modern medicine and are anticipated to have several uses in daily life. In this connection, various techniques have been developed to create novel pyridine derivatives, such as multicomponent one-pot reactions, green catalysts, environmentally friendly solvents, solvent-free synthesizing, ultrasonic production, and microwave-assisted synthesis. This study unifies the synthesis of various pyridine-based molecular frameworks using green protocols and the results will support new ideas for creating biologically active compounds.
吡啶是重要的六元氮杂环之一，因其是多种具有重要药用价值的天然产物的组成部分而受到科学界的关注。由于吡啶衍生物在制药、医学和农业等诸多领域有广泛应用，其市场规模可观且不断扩大。许多化学物质正在进行临床研究测试，其中吡啶类似物占据首位。吡啶骨架在现代医学应用中也日益突出，预计在日常生活中有多种用途。在这方面，已经开发了各种技术来制备新型吡啶衍生物，如多组分一锅法反应、绿色催化剂、环境友好型溶剂、无溶剂合成、超声制备和微波辅助合成。本研究采用绿色方法统一合成了各种基于吡啶的分子骨架，其结果将为创造生物活性化合物提供新思路。
