Balfagón G, Arranz J A, Marco E J
Gen Pharmacol. 1985;16(2):109-14. doi: 10.1016/0306-3623(85)90045-x.
Superfused cat atrial fragments preincubated with [3H]noradrenaline showed an increased tritium release under the action of 10(-4) M histamine. Reserpine pretreatment of the animals, external calcium removal or the presence of 10(-6) M cocaine, 10(-6) M diphenhydramine or 10(-3) M colchicine in the superfusion medium significantly reduced this effect of histamine (10(-4) M). Diphenhydramine (10(-5) M) also decreased the release of tritium brought about by 10(-6) M tyramine. These results suggest that histamine may release neurotransmitter from cardiac sympathetic nerve endings by means of an exocytotic process and needs to enter the nerve terminals through the amine uptake system.
预先用[3H]去甲肾上腺素预孵育的灌流猫心房片段，在10(-4)M组胺作用下显示氚释放增加。对动物进行利血平预处理、去除细胞外钙或在灌流介质中加入10(-6)M可卡因、10(-6)M苯海拉明或10(-3)M秋水仙碱，可显著降低组胺（10(-4)M）的这种作用。苯海拉明（10(-5)M）也可减少10(-6)M酪胺引起的氚释放。这些结果表明，组胺可能通过胞吐过程从心脏交感神经末梢释放神经递质，并且需要通过胺摄取系统进入神经末梢。
