Marco E J, Balfagón G, Conde M V
J Pharm Pharmacol. 1984 Apr;36(4):253-5. doi: 10.1111/j.2042-7158.1984.tb04360.x.
Histamine (10(-4) M) increased the radioactivity released from human cerebral arteries obtained within 6 h of death and preincubated with [3H]noradrenaline. In the presence of 10(-6) M cocaine or if 7 or more hours had elapsed since death, 10(-4) M histamine was unable to change basal levels of tritium outflow. The radioactivity retained by the tissue was higher when cerebral blood vessels were obtained within a post-mortem period of 6 h. These results suggest that histamine may release noradrenaline from the sympathetic innervation of human cerebral arteries and that the function of this innervation lasts only 6 h after death.
组胺（10⁻⁴ M）增加了从死亡6小时内获取并预先与[³H]去甲肾上腺素一起孵育的人脑动脉释放的放射性。在存在10⁻⁶ M可卡因的情况下，或者如果自死亡后已经过去了7小时或更长时间，10⁻⁴ M组胺无法改变氚流出的基础水平。当在死后6小时内获取脑血管时，组织保留的放射性更高。这些结果表明，组胺可能从人脑动脉的交感神经支配中释放去甲肾上腺素，并且这种神经支配的功能在死亡后仅持续6小时。
