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老年股骨转子间骨折PFNA内固定术后影响髋关节功能恢复因素的列线图预测模型的构建与验证

Construction and validation of a nomogram prediction model for factors affecting hip functional recovery after PFNA internal fixation of intertrochanteric femur fractures in the elderly.

作者信息

Jiang Wan-Zhong

机构信息

Ya'an Hospital of Traditional Chinese Medicine, Ya'an, China.

出版信息

Medicine (Baltimore). 2024 Dec 27;103(52):e41043. doi: 10.1097/MD.0000000000041043.

Abstract

A nomogram prediction model was developed with the aim of identifying and analyzing which independent risk factors affect the recovery of hip function in elderly patients with intertrochanteric femur fractures after undergoing proximal femoral anti-rotation intramedullary nailing (PFNA) internal fixation. We collected detailed data on elderly patients with intertrochanteric femur fractures from January 2018 to December 2022 in a tertiary hospital in China. By applying univariate and multivariate logistic regression analysis, we systematically screened and identified the independent risk factors affecting the recovery of hip function after PFNA internal fixation. Based on these risk factors, we further constructed a corresponding nomogram prediction model. In order to comprehensively evaluate the predictive performance of the model, we not only plotted the receiver operating characteristic curve and calculated the area under the curve, but also produced the calibration curve and decision curve. Of the total 646 patients included, 510 patients had good hip function recovery and were categorized as the excellent hip function group, while the other 136 patients had poor hip function recovery and were categorized as the poor hip function group. After rigorous unifactorial and multifactorial logistic regression analyses, we identified 5 key risk factors, which were: fracture instability, posterolateral wall type III, posterolateral wall thickness less than or equal to 2 cm, cusp distance >25 mm, and delayed postoperative weight-bearing. Together, these factors constitute the main risk factors affecting the recovery of hip function after PFNA internal fixation of intertrochanteric femur fractures in the elderly. In this study, a nomogram prediction model for the recovery of hip function after PFNA internal fixation of intertrochanteric femur fractures in the elderly was successfully constructed, and the model demonstrated good prediction accuracy. This not only provides a powerful tool for orthopedic surgeons so that they can identify and intervene in advance with risk factors that may affect patients' hip functional recovery, but also provides a scientific basis for developing more precise and personalized treatment strategies.

摘要

开发了一种列线图预测模型,旨在识别和分析哪些独立危险因素会影响老年股骨转子间骨折患者在接受股骨近端抗旋髓内钉(PFNA)内固定后髋关节功能的恢复。我们收集了2018年1月至2022年12月在中国一家三级医院的老年股骨转子间骨折患者的详细数据。通过应用单因素和多因素逻辑回归分析,我们系统地筛选并确定了影响PFNA内固定后髋关节功能恢复的独立危险因素。基于这些危险因素,我们进一步构建了相应的列线图预测模型。为了全面评估该模型的预测性能,我们不仅绘制了受试者工作特征曲线并计算了曲线下面积,还生成了校准曲线和决策曲线。在纳入的646例患者中,510例患者髋关节功能恢复良好,被归类为髋关节功能优良组,而其他136例患者髋关节功能恢复较差,被归类为髋关节功能不良组。经过严格的单因素和多因素逻辑回归分析,我们确定了5个关键危险因素,分别为:骨折不稳定、Ⅲ型后外侧壁、后外侧壁厚度小于或等于2 cm、尖距>25 mm以及术后延迟负重。这些因素共同构成了影响老年股骨转子间骨折PFNA内固定后髋关节功能恢复的主要危险因素。在本研究中,成功构建了老年股骨转子间骨折PFNA内固定后髋关节功能恢复的列线图预测模型,且该模型显示出良好的预测准确性。这不仅为骨科医生提供了一个有力工具,使他们能够识别并提前干预可能影响患者髋关节功能恢复的危险因素,还为制定更精确和个性化的治疗策略提供了科学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9211/11688005/059f77c1b55b/medi-103-e41043-g001.jpg

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