Valbonesi M, Montani F, Mosconi L, Zerbi D, Beltramelli A, Florio G
Haematologia (Budap). 1985;18(1):33-43.
Data concerning 37 patients with inflammatory dysimmune polyneuropathy treated by discontinuous flow centrifugation, membrane plasma separation and cascade filtration are presented. Plasmapheresis was combined with immunosuppressants in patients with chronic or relapsing neuropathy (8 patients), cryoglobulinemic (6 patients) and paraneoplastic disease (2 patients), whereas 21 patients with acute Guillain-Barré syndrome (GBS) underwent exclusively plasmapheresis. Most patients were treated during the onset or progression of their disease and excellent or satisfactory clinical results were obtained in 18 patients with GBS, 6 with cryoglobulinemia, 2 with paraneoplastic disease and 4 with chronic relapsing polyneuropathy. Prior to therapy, 34 patients had high levels of immune complexes (CIC); this level was clearly reduced by plasmapheresis and clinical results correlated well with this removal. 3 patients with chronic dysimmune polyneuropathy, without any evidence of CIC, were completely unaffected by treatment. The possible role of CIC in demyelinating polyneuropathies is discussed on the basis of information given by cascade filtration treatment of 7 patients.
本文介绍了37例采用间断流动离心、膜血浆分离和级联过滤治疗的炎性免疫性多神经病患者的数据。对于慢性或复发性神经病患者（8例）、冷球蛋白血症患者（6例）和副肿瘤性疾病患者（2例），血浆置换联合免疫抑制剂治疗；而21例急性吉兰-巴雷综合征（GBS）患者仅接受血浆置换治疗。大多数患者在疾病发作或进展期接受治疗，18例GBS患者、6例冷球蛋白血症患者、2例副肿瘤性疾病患者和4例慢性复发性多神经病患者获得了优异或满意的临床结果。治疗前，34例患者免疫复合物（CIC）水平较高；血浆置换明显降低了该水平，临床结果与这种清除效果密切相关。3例慢性免疫性多神经病患者无CIC证据，治疗对其完全无效。基于7例患者的级联过滤治疗信息，讨论了CIC在脱髓鞘性多神经病中的可能作用。
