用于分子超声造影的铁卟啉共轭聚天冬酰胺O型微泡
O-microbubble of iron-porphyrin conjugated polyaspartamide for molecular ultrasound contrast effect.
作者信息
Cho Yoon Na, Lim Jun Woo, Oh Seung Joo, Han Sa Ra, Cho Sungwoo, Jeong Jimin, Han Byoung Hee, Jeong Jae Hyun
机构信息
Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Dongjak-Gu, Seoul, 06978, Republic of Korea.
Department of Radiology, GangNeung Asan Hospital, Gangneung, Ganwon-do, Republic of Korea.
出版信息
Biotechnol Lett. 2025 Feb 19;47(2):28. doi: 10.1007/s10529-025-03571-x.
OBJECTIVE
This study aimed to prepare oxygen-microbubbles incorporating ferrous porphyrin to emulate the oxygen-capturing ability of hemoglobin porphyrin in red blood cells.
RESULTS
We synthesized poly(2-hydroxyethyl aspartamide) (PHEA) grafted with ferrous porphyrins (Iron-P-PHEA) and created microbubbles using 1,2-dipalmitoyl-sn-glycero-3-phosphocholine. These microbubbles trapped oxygen and retained it over a 2 h period. The O-microbubbles demonstrated an enhanced photoacoustic effect as an ultrasound contrast agent, as confirmed by Doppler ultrasound testing.
CONCLUSIONS
The innovative strategy for O-microbubble preparation enhances the efficiency of targeted delivery in molecular optical and ultrasound imaging.
目的
本研究旨在制备负载亚铁卟啉的氧微泡，以模拟红细胞中血红蛋白卟啉的氧捕获能力。
结果
我们合成了接枝有亚铁卟啉的聚（2-羟乙基天冬酰胺）（铁-P-聚羟乙基天冬酰胺），并使用1,2-二棕榈酰-sn-甘油-3-磷酸胆碱制备了微泡。这些微泡捕获氧气并在2小时内保持氧气。经多普勒超声测试证实，氧微泡作为超声造影剂表现出增强的光声效应。
结论
氧微泡制备的创新策略提高了分子光学和超声成像中靶向递送的效率。
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