Shimizu Daisuke, Takigawa Hidehiko, Kitadai Yuki, Ariyoshi Misa, Miyamoto Ryo, Hiyama Yuichi, Urabe Yuji, Ishikawa Akira, Kuwai Toshio, Oka Shiro
Department of Gastroenterology, Hiroshima University Hospital, Japan.
Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Intern Med. 2025 Aug 15;64(16):2452-2457. doi: 10.2169/internalmedicine.4907-24. Epub 2025 Feb 18.
A 77-year-old man underwent a colonoscopy. A submucosal cecal tumor was found, and localized colorectal MALT lymphoma (Lugano stage I) was diagnosed with a Helicobacter pylori infection. The first-line eradication therapy was successful, and the cecal lesion regressed. However, a new lesion was observed in the lower rectum. The rectal lesion regressed after the second-line eradication therapy. Two new lesions were identified in the sigmoid colon. However, no additional treatment was administered and a watch-and-wait strategy was adopted. Both of the lesions regressed. There are no established treatments for colorectal MALT lymphomas. The watch-and-wait strategy may be effective in cases of recurrence after eradication therapy.
一名77岁男性接受了结肠镜检查。发现了一个盲肠黏膜下肿瘤，诊断为局限性结直肠黏膜相关淋巴组织淋巴瘤（卢加诺分期I期），伴有幽门螺杆菌感染。一线根除治疗成功，盲肠病变消退。然而，在直肠下段发现了一个新病变。二线根除治疗后直肠病变消退。在乙状结肠发现了两个新病变。然而，未给予额外治疗，而是采取了观察等待策略。两个病变均消退。结直肠黏膜相关淋巴组织淋巴瘤尚无既定的治疗方法。观察等待策略可能对根除治疗后复发的病例有效。
